游离雌三醇和人胎盘催乳素测定在子痫前期的意义  

Clinical Significance of determination of unconjugated estriol and human placental lactogen in preeclampsia

作　　者：白雪 范祎 

机构地区：[1]广州市妇女儿童医疗中心产前诊断中心,广东广州510623 [2]广州市妇女儿童医疗中心妇产科,广东广州510623

出　　处：《国际检验医学杂志》2015年第13期1870-1871,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清游离雌三醇（uE3）和人胎盘催乳素（hPL）与子痫前期的关系。方法选取2013年6月至2014年6月诊断为子痫前期的孕妇123例纳入观察组,同期健康孕妇150例纳入对照组,两组孕妇均分别在妊娠28~〈32周和妊娠32~36周各采血一次,检测血清uE3和hPL水平并进行比较。结果对照组妊娠结局优于观察组。随着孕周增加两组孕妇血清uE3和hPL水平有升高趋势,在相同孕期中对照组血清uE3和hPL水平均较观察组高,差异均有统计学意义（P〈0.05）。结论子痫前期孕妇血清uE3和hPL水平下降,与妊娠结局相关。Objective To explore the relationship between serum levels of unconjugated estriol （uE3）and human placental lacto-gen （hPL）and preeclampsia.Methods 123 cases of pregnant women diagnosed as preeclampsia were enrolled into observational group,and 1 50 cases of healthy pregnant women were enrolled into control group.Blood specimen were collected from the two groups in 28-〈32 gestational weeks and 32-36 gestational weeks.Serum levels of uE3 and hPL were determined and compared between the two groups.Results The pregnancy outcomes of the control group were better than those of the observation group. With the increase of gestational age,there was increasing trend of serum levels of uE3 and hPL in the two groups.However,com-pared with the observation group,the serum levels of uE3 and hPL were higher in the control group,and the differences were statis-tically significant（P 〈0.05）.Conclusion The decrease of serum levels of uE3 and hPL in pregnant women with preeclampsia may be associated with the pregnancy outcomes.

关 键 词：子痫前期 游离雌三醇 人胎盘催乳素 妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学] R446.1[医药卫生—临床医学]