慢性乙型肝炎妊娠晚期HBeAg及HBV DNA对产后肝脏炎症的影响  

The effects of HBeAg and HBV DNA in chronic hepatitis B during late trimester of pregnancy on the postpartum hepatic inflammation

作　　者：丁伯泉 

机构地区：[1]广东省茂名农垦医院检验科,广东茂名525200

出　　处：《国际检验医学杂志》2015年第13期1881-1882,1885,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨慢性乙型肝炎（CHB）女性患者妊娠晚期乙型肝炎e抗原（HBeAg）及乙型肝炎病毒（HBV）DNA载量对产后慢性乙型肝炎急性发作的影响。方法选取2010年3月至2014年6月收治的CHB孕妇114例,分为肝炎急性发作组与无肝炎发作组,收集患者一般人口学资料及临床资料,检测妊娠晚期（妊娠28~36周）及产后（产后6~12周）HBV DNA载量与丙氨酸氨基转氨酶（ALT）水平,并分析HBeAg及HBV DNA载量对产后肝炎急性发作的影响。结果 24.6%的CHB患者产后肝炎急性发作。妊娠晚期HBeAg阳性CHB患者产后肝炎急性发作的概率较HBeAg阴性患者增高,差异有统计学意义（P〈0.05）。两组妊娠晚期及产后血清HBV DNA载量差异均无统计学意义（P〉0.05）。结论 CHB患者产后肝炎急性发作与HBV DNA载量无关,但与HBeAg状态有相关,妊娠晚期HBeAg阳性可能是产后发生肝炎急性发作的危险因素。Objective To explore the effects of hepatitis B e-antigen（HBeAg）and hepatitis B virus（HBV）DNA load during late trimester of pregnancy on postpartum chromic hepatitis B with acute exacerbation in female patients with chronic hepatitis B （CHB）.Methods 1 14 cases of pregnant women with CHB treated in this hospital from March 2010 to June 2014 were selected and divided into the hepatitis B with acute exacerbation group and hepatitis B without acute exacerbation group.The general demograph-ic data and clinical information of these patients were collected,and serum HBV DNA loads and levels of alanine aminotransferase （ALT）were detected during late trimester of pregnancy（between the 28th to 36th weeks of pregnancy）and postpartum（6 to 12 weeks postpartum）.The effects of HBeAg and HBV DNA loads on postpartum chromic hepatitis B with acute exacerbation were analysed.Results 24.6% of female patients was diagnosed with postpartum chromic hepatitis B with acute exacerbation.The inci-dence rate of postpartum chromic hepatitis B with acute exacerbation in female patients with positive HBeAg during late trimester of pregnancy increased,compared those with negative HBeAg,had statistically significant differences（P 〈0.05）.While there were no statistical differences in the serum HBV DNA loads between the two groups during late trimester of pregnancy and postpartum （P 〉 0.05）.The hepatic flare was correlated with the HBeAg status,but was not related with HBV DNA load.Conclusion Post-partum chromic hepatitis B with acute exacerbation might not be correlated with HBV DNA loads,but correlated with HBeAg, which indicates that positive HBeAg during late trimester of pregnancy could be a risk factor for postpartum chromic hepatitis B with acute exacerbation.

关 键 词：慢性乙型肝炎 妊娠 慢性乙型肝炎急性发作 乙型肝炎E抗原 

分 类 号：R714.251[医药卫生—妇产科学] R440[医药卫生—临床医学]