梅毒检测在孕前优生健康检查中的应用  

The application of syphilis detection in the pre-pregnancy eugenics inspection

作　　者：李银清 麦爱平 谭遥 刘锡英 

机构地区：[1]清远市清城区人口和计划生育服务站,广东清远511518

出　　处：《国际检验医学杂志》2015年第13期1891-1892,1895,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨梅毒检测在孕前优生健康检查中的应用。方法以2011年3月至2013年10月进行国家免费孕前优生健康检查的妇女12 900例为研究对象,均进行梅毒螺旋体抗原血清试验(TPPA)和快速血浆反应素环状(RPR)试验孕前检查,记录检测结果并进行比较。结果 12 900例待孕妇女中,RPR试验阳性63例(0.49%),TPPA试验阳性129例(1.00%),RPR及TPPA试验均阳性45例(0.35%)。RPR试验阳性率与TPPA试验阳性率比较差异有统计学意义(P<0.05),而与RPR联合TPPA试验阳性率比较差异无统计学意义(P>0.05);TPPA试验阳性率与RPR联合TPPA试验阳性率比较差异有统计学意义(P<0.05)。RPR试验灵敏度为71.4%,TPPA试验灵敏度为34.9%。结论 RPR试验和TPPA试验都是梅毒诊断快速而有效的方法,其中RPR试验的灵敏度较TPPA试验高,可在孕前优生健康检查的筛查中推广,而RPR试验联合TPPA试验可做进一步确诊。Objective To investigate the application of syphilis detection in the pre-pregnancy eugenics inspection.Methods 12 900 women who attended the national free pre-pregnancy eugenics inspection from March 201 1 to October 2013 were selected as subjects.The treponema pallidum particle agglutination assay（TPPA）and rapid plasma regain test（RPR）were conducted among them before pregnancy,and the results of syphilis detections were recorded and compared.Results In 12 900 women,63 cases （0.49%）were syphilis positive in RPR tests,129 cases（1.00%）were syphilis positive in TPPA test,and 45 cases（0.35%）were syphilis positive both in RPR and TPPA tests.There were significant differences in positive rates of syphilis between that in the RPR test and that in the TPPA test（P 〈0.05）,while no significant differences were found in positive rates of syphilis between that in the RPR test and that in the combined detection of RPR test and TPPA test.There were significant differences in positive rate of syphilis between that in the TPPA test and that in the combined detection of RPR test and TPPA test（P 〈0.05）.The sensitivity of RPR test and TPPA test was 71.4% and 34.9%,respectively.Conclusion Both the RPR test and TPPA test could be the fast and ef-fective method in diagnosis of syphilis.However,RPR test might be more sensitive,which could be widely used in the pre-pregnancy eugen-ics healthy screening.Moreover,the diagnosis results could be confirmed by combination of RPR test and TPPA test.

关 键 词：梅毒检测 梅毒螺旋体抗原血清试验 快速血浆反应素环状卡片试验 孕前优生健康检查 

分 类 号：R169.1[医药卫生—公共卫生与预防医学]