耐亚胺培南铜绿假单胞菌头孢哌酮/舒巴坦与阿米卡星联合用药评估  

Evaluation of combined effects of cefoperazone/sulbactam and amikacin against strains of imipenem-resistant Pseudomonas aeruginosa

作　　者：彭健桥 曾赤佳 李帼宁 仇杭佳 马均宝[2] 

机构地区：[1]佛山市禅城区中心医院检验科,广东佛山528031 [2]佛山市第一人民医院检验科,广东佛山528000

出　　处：《国际检验医学杂志》2015年第13期1902-1904,共3页International Journal of Laboratory Medicine

摘　　要：目的分析佛山地区耐亚胺培南铜绿假单胞菌对常用抗菌药物的耐药特征,探讨头孢哌酮/舒巴坦与阿米卡星联合使用的药敏情况。方法收集2011年1月至2014年9月临床分离的耐亚胺培南铜绿假单胞菌,分析其对常用抗菌药物的耐药情况,并采用微量棋盘稀释法测定头孢哌酮/舒巴坦与阿米卡星联合使用对耐亚胺培南铜绿假单胞菌的药敏情况,计算部分抑菌浓度(FIC)指数。结果分离的1 000株耐亚胺培南铜绿假单胞菌对16种抗菌药物的耐药率总体呈逐年上升趋势。两种抗菌药物联合使用主要表现为协同作用(76.0%)和相加作用(20.3%),有3.7%的菌株表现为无关作用,未发现拮抗作用。结论佛山地区耐亚胺培南铜绿假单胞菌的耐药率逐年上升,头孢哌酮/舒巴坦和阿米卡星联合对绝大多数菌株表现为协同作用或相加作用,临床医生应关注各种抗菌药物的耐药谱变化,并根据药敏结果合理选用抗菌药物。Objective To investigate the characteristics of resistance of imipenem-resistant Pseudomonas aeruginosa to common-ly used antibacterial agents in Foshan area,and to explore sensitivity of combined utilization of cefoperazone/sulbactam and amikacin against strains of imipenem-resistant Pseudomonas aeruginosa.Methods Collected clinical isolates of imipenem-resistant Pseudo-monas aeruginosa from January 201 1 to September 2014,and the characteristics of resistance of imipenem-resistant Pseudomonas aeruginosa to commonly used antibacterial agents were analysed.The sensitivity of combined utilization of cefoperazone/sulbactam and amikacin against strains of imipenem-resistant Pseudomonas aeruginosa was assessed by using microscale checkerboard dilution method,and the fractional inhibitory concentration （FIC）index was calculated.Results A total of 1 000 strains of imipenem-resist-ant Pseudomonas aeruginosa were isolated,and their resistance rates against 1 6 kinds of commonly used antibacterial agents in-creased year by year.The FIC results of cefoperazone/sulbactam combined with amikacin suggested that the main interaction was synergism （76.0%）and additivity （20.3%）,with only 3.7% of non-effect.No antagonism was observed.Conclusion Antibacteri-al resistance of imipenem-resistant Pseudomonas aeruginosa increase year by year.The interaction of cefoperazone/sulbactam and amikacin is characterized by synergism and additivity.The clinicians should pay attention to changes of resistance spectrum in vari-ous antibacterial agents,and promote rational use of antibacterial agents according to results of antibacterial-susceptibility test.

关 键 词：铜绿假单胞菌 亚胺培南 耐药性 联合用药 

分 类 号：R446.5[医药卫生—诊断学]