7AAP/PTA自组装复合胶体微球的制备及其性能研究  

Preparation and Properties Evaluation of 7AAP/PTA Self-assembled Hybrid Colloidal Spheres

作　　者：肖瑞秋 公晓 权静[1] 聂华丽[1,2] 朱利民[1] 李树白[3] 

机构地区：[1]东华大学化学化工与生物工程学院,上海201620 [2]东华大学国家染整工程技术研究中心,上海201620 [3]常州工程职业技术学院,常州213164

出　　处：《材料导报》2015年第12期67-70,99,共5页Materials Reports

基　　金：上海市自然科学基金(14ZR1401300);常州市应用基础研究计划(CJ20120014);常州工程技术学院科研基金(202152001);2014年度高校"青蓝工程"

摘　　要：在水相中利用七肽7AAP与磷钨酸(PTA)进行自组装,制备了7AAP/PTA复合胶体球形颗粒。采用红外光谱(FTIR)、扫描电镜(SEM)和紫外可见分光光谱(UV-Vis)等分析方法对自组装行为进行了研究。实验结果表明,7AAP与PTA在酸性条件下能自组装形成球形颗粒。当pH为5、PTA与7AAP的物质的量比为1∶4.5时,获得的球形颗粒分散性良好,形状规整。此外,该颗粒具有较好的温度敏感性,可能在药物缓释方面具有潜在应用。7AAP was assembled into novel hybrid colloidal spheres by regulating agent-PTA in the aqueous condition.The assembled hybrid colloidal spheres were characterized by FTIR,SEM and UV-Vis.The results showed that 7AAP and PTA could assemble into spherical particles in the acidic conditions.The colloidal spheres with uniform shape and good dispersion could be obtained when the pH value of aqueous phase was 5 and the molar ratio of PTA and 7AAP was 1 ∶4.5.Moreover,the as-prepared hybrid colloidal spheres were temperature sensitive.This could be a potential carrier for drug controlled release.

关 键 词：7AAP 磷钨酸 自组装 温敏性 

分 类 号：TB34[一般工业技术—材料科学与工程]