星点设计-效应面法优选无糖型胃炎灵颗粒剂中的挥发油提取工艺  

Optimization of Extraction Process of Volatile Oil from Sugar-free Type Weiyanling Granules by Central Composite Design-Response Surface Methodology

作　　者：王建平 张咏梅 陈晓峰 张月婵 钱伟 

机构地区：[1]张家港市中医医院,江苏张家港215600

出　　处：《现代中药研究与实践》2015年第3期53-55,共3页Research and Practice on Chinese Medicines

基　　金：苏州市科技发展计划(应用基础研究-医药卫生)(SYSD2012136)

摘　　要：目的优选无糖型胃炎灵颗粒剂中挥发油的提取工艺。方法采用水蒸气蒸馏法提取香附、莪术、枳实和郁金中挥发油,以挥发油收率为因变量,采用星点设计考察加水量、浸泡时间和蒸馏时间对挥发油提取工艺的影响,对试验结果进行多元线性回归和二项式拟合,效应面法优选最佳工艺条件,并进行预测分析和验证试验。结果由复相关系数可知,二项式拟合方程优于多元线性回归方程,确定最佳工艺条件为加10倍量水浸泡70 min,蒸馏提取9 h。结论该工艺简便、预测性良好,为无糖型胃炎灵颗粒的工艺改进提供了试验依据。Objective To optimize extraction technology conditions of volatile oil from Sugar-free type Weiyanling granules. Methods Volatile oil from Rhizoma Cyperi, Curcuma Zedoary, Fructus Auranti immaturus, Radix Curcumae were extracted by steam distillation method, with yield of volatile oil asevaluation index, the amount of water, soaking time and extraction time were investigated by central composite design, test data was fitted by multi-linear equation and second-order polynomial equation, extraction technology conditions were optimized by response surface method,to predictive analysis and verification test. Results Multiple correlation coefficients from second-order polynomial equation were prior to those from multi-linear equation,optimum extraction process conditions were as follows： soaked 70 min with 10 times the amount of water, distillation time 9 h. Conclusion This optimized process was simple with high predictability, it could provide test basis for industrial production of Sugar-free type Weiyanling granules.

关 键 词：星点设计-效应面法 无糖型胃炎灵颗粒 挥发油 提取工艺 

分 类 号：R944.27[医药卫生—药剂学]