云厚朴SFE-CO_2萃取物中厚朴酚与和厚朴酚的热稳定性考察  

The thermal stability of magnolol and honokiol in the SFE-CO_2 extract of Magnolia rostrata

作　　者：魏泽英[1] 朱培芳[1] 孙海林[1] 李丽梅[1] 杨文标[1] 

机构地区：[1]云南中医学院药学院,昆明650500

出　　处：《重庆大学学报（自然科学版）》2015年第3期154-158,共5页Journal of Chongqing University

基　　金：云南省教育厅科学研究基金理工类重点项目(2012Z128C)~~

摘　　要：温度是影响云厚朴提取物稳定性的主要因素,本研究考察云厚朴提取物的热稳定性。采用高效液相色谱法,测定云厚朴SFE-CO2(二氧化碳超临界流体萃取)工艺萃取物中的和厚朴酚、厚朴酚在不同温度干燥时的含量变化并得出降解规律,干燥时降解为一级反应,在100℃降解较快。采用恒温加速实验,得出SFE-CO2萃取液中的和厚朴酚、厚朴酚室温25℃贮存期分别为1 125.6h和975.7h。在制剂生产中,云厚朴SFE-CO2萃取物不宜长时间贮存,以减少有效成分损失;由于热不稳定性,高温干燥会导致制剂质量不稳定,降低药效,应在较低温度下干燥。Temperature is the main factor that affects the stability of magnolia rostrata extract.The thermal stability of magnolia rostrata extract is studied.The contents of honokiol and magnolol in the extract obtained by CO2-supercritical fluid extraction（SFE-CO2）were determined by HPLC during the drying process at different temperatures,and the degradation equations of these two ingredients were explored.The degradation reactions of magnolol and honokiol in the drying process were first-order,and the rate of degradation was faster at 100℃.Higher temperatures were selected to examine the accelerated degradation isothermally,and the shelf lives of honokiol and magnolol were found to be 1125.6hand 975.7hat 25℃.In order to guarantee the preparation quality lower temperature and shorter time during drying and storage for the SFE-CO2 extract of magnolia rostrata is preferable.

关 键 词：厚朴酚 和厚朴酚 化学动力学 高效液相色谱法 超临界流体萃取 

分 类 号：R284[医药卫生—中药学]