主动脉夹层DeBakey Ⅲ型发生相关因素的临床研究  

Case-control study of factors associated with aortic dissection De Bakey type Ⅲ

作　　者：谷梦楠[1,2] 罗建方 黄文晖[2] 薛凌[2] 陈纪言[2] 

机构地区：[1]南方医科大学,广州市510515 [2]广东省人民医院,广东省医学科学院,广州市510080

出　　处：《实用医学杂志》2015年第12期1929-1932,共4页The Journal of Practical Medicine

基　　金：广东省科技计划资助项目(编号:2012B031800318)

摘　　要：目的：探究主动脉夹层DeBakey Ⅲ型发生相关的危险因素及保护因素。方法：入选2014年5－9月在广东省人民医院心血管病内科病房住院的主动脉夹层 DeBakey Ⅲ型患者43例为病例组，另外入选27例排除夹层的志愿者为对照组，采集各项检验指标，采用χ2检验或 t 检验进行两样本单因素分析，在此基础上进一步采用多因素 Logistic 回归分析探讨与主动脉夹层 DeBakey Ⅲ型发生相关的危险因素及保护因素。结果：与对照组相比，病例组患者中高血压病患病率（93．02％vs．18．52％， P＝0．000）、吸烟者比例（34．88％vs．11．11％， P＝0．027）等指标有显著统计学差异。多因素Logistic回归分析显示高血压病（OR＝5．148，95％CI ＝[2．209～13．058]， P ＝0．001）及血浆白蛋白水平（OR ＝0．709，95％CI ＝[0．541～0．929]， P ＝0．013）与主动脉夹层DeBakey Ⅲ型发生密切相关。结论：高血压病是主动脉夹层Debakey Ⅲ型发生的独立危险因素，而血浆白蛋白水平是其保护因素。Objectives To investigate the recurrence risk factors and the protective factors of aortic dissection （AD） DeBakey type Ⅲ. Methods 43 patients with AD DeBakey type Ⅲ who were in Guangdong General Hospital from May 2014 to September 2014, were enrolled as the case group, while 27 volunteers exclude AD as the control group. Blood chemistries and other information obtained immediately after admissions , χ2 test or T test was used for univariate analysis of independent samples. Multivariate Logistic regression analysis was used to screen patients with recurrence risk factors or protective factors. Results The prevalence of hypertension （93.02%vs. 18.52%, P = 0.000） and proportion of smokers （34.88% vs. 11.11%, P = 0.027） were significantly higher in case group than control group. Logistic regression analysis showed that hypertension （OR=5.148, 95%CI= [2.209~13.058], P=0.001） and albumin level （OR=0.709, 95%CI = [0.541~0.929], P=0.013） were significantly associated with recurrence of aortic dissection DeBakey type Ⅲ. Conclusion Hypertension is an independent risk factor for recurrence of aortic dissection DeBakey type Ⅲ, and albumin level is a protective factor.

关 键 词：高血压 主动脉夹层 血浆白蛋白 相关因素 

分 类 号：R543.1[医药卫生—心血管疾病]