石河子市社区高血压患者血清钙/钙调蛋白依赖性蛋白激酶Ⅳ水平的相关性  

Correlation between the level of Ca2+/calmodulin-dependent protein kinases IV and essential hypertension in Shihezi community

作　　者：王忠[1] 陈少泽[1] 赵若飞[2] 杨军[3] 王丽[1] 翟志红[1] 任宏强[1] 郑丽华[2] 

机构地区：[1]石河子大学医学院第一附属医院心内二科,832008 [2]石河子大学医学院,832000 [3]石河子大学医学院第一附属医院中心实验室,832008

出　　处：《实用医学杂志》2015年第12期1942-1944,共3页The Journal of Practical Medicine

基　　金：石河子大学重大科技攻关计划(编号:gxjs2013-zdgg06)

摘　　要：目的：研究石河子市社区高血压患者血清CaMKIV与原发性高血压的关系。方法：选择石河子市15社区高血压患者146例，血压正常者142例，收集血压、体质指数、腰围、血脂等指标，采用ELISA法检测血清中 CaMKIV 水平，运用 SPSS 17．0统计软件进行数据分析。结果：对照组血清 CaMKIV 高于高血压组（P ＜0．05）；原发性高血压组血清CaMKIV与TC、TG、HDL-C、LDL-C均无相关性（P ＞0．05），与收缩压、舒张压呈负相关，且与后者相关性更加明显（r分别为－0．304、－0．452，P均＜0．05）；与舒张压≥100 mmHg 组相关性更加明显（r ＝－0．571，P ＜0．05）；Logistic 回归分析示CaMKIV是高血压的保护因素[OR（95％CI）为0．919（0．904～0．957）]。结论：CaMKIV与原发性高血压血压值呈负相关，是原发性高血压的独立影响因素。Objective To study the correlation between the level of CaMKIV and essential hypertension （EH） in Shihezi community. Methods One hundred and forty-six patients with EH and 142 with normal blood pressure are enrolled from 15 communities in shihezi. We collected the clinical data, including blood pressure, body mass index, waist circumference, blood lipids. The serum level of CaMKIV was detected using an enzyme linked immunosorbent assay. Results The serum level of CaMKIV in the EH group was significantly lower than that in the normal blood pressure group （P 〈 0.05）. The serum CaMKIV was negatively correlated with systolic BP and diastolic BP （r = -0.304, -0.452, all P 〈 0.05）, with more obvious correlation with patients whose diastolic blood pressure was over 100 mmHg （r = -0.571, P 〈 0.05）. Conclusions The serum level of CaMKIV is negatively correlated with EH, which is an independent factor of EH.

关 键 词：高血压 原发性 钙调蛋白依赖性蛋白激酶Ⅳ 社区 

分 类 号：R544.1[医药卫生—心血管疾病]