压力导丝在冠心病弥漫性长病变介入治疗中的应用  

Application of pressure wire in intervention treatment of diffuse coronary artery

作　　者：李旭东[1] 路雯[1] 李明哲[1] 吴强[1] 王临光[1] 黄宜杰 

机构地区：[1]徐州市中心医院心内科,江苏徐州221000

出　　处：《临床荟萃》2015年第7期755-757,共3页Clinical Focus

摘　　要：目的探讨压力导丝测定心肌血流储备分数(FFR)在冠心病弥漫性长病变介入治疗中的应用。方法选取72例经冠状动脉造影(CAG)明确存在弥漫性长病变的冠心病患者,对照组35例(40处病变),依术者临床经验选择常规经皮冠状动脉介入治疗(PCI)或药物治疗;观察组37例(43处病变),通过压力导丝回撤技术测定FFR,观察FFR曲线是否存在明显压力"跳跃",对出现"跳跃"处的病变行介入治疗,对未见明显"跳跃"的病变行药物治疗。结果两组患者冠状动脉病变程度比较差异无统计学意义,对照组植入药物支架33个,观察组植入药物支架19个,差异具有统计学意义(P<0.05)。半年观察期中,观察组心绞痛发生率明显低于对照组,差异具有统计学意义(P<0.05),而主要不良心血管事件(MACE)发生率两组差异无统计学意义。结论 FFR指导下PCI治疗冠心病弥漫性病变安全有效,减少了支架植入数量,且具有良好的预后。Objective To investigate the application effects of fractional flow reserve（FFR）detected by pressure wire in the intervention treatment of diffuse coronary artery.Methods The study selected 72 patients with diffuse coronary artery detected by cardioangiography,35 cases（40 lesions）received general percutaneous coronary intervention（PCI）or medication with clinical experience as control group,37cases（43lesions）received PCI as FFR with leaping and medication as FFR without leaping,FFR was detected by pressure wire pull back method as observation group.Results There were no differences in lesion degree of coronary artery between two groups.33 drug eluting stents（DES）were used in control group and 19 DES were used in observation group with statistic significance（P〈0.05）.In the half year＇s follow-up,the occurrence of angina pectoris in observation group was lower than that of control group（P〈0.05）,but there were no differences in major adverse cardiovascular events（MACE）incidences between two groups.Conclusion The PCI treatment under the guidance of FFR for diffuse coronary artery lesion is safe and useful,which can reduce implanted stents with satisfactory prognosis.

关 键 词：冠状动脉疾病 压力导丝 血流储备分数 

分 类 号：R541.4[医药卫生—心血管疾病]