PON-1基因多态性对急性有机磷中毒患者病情的影响  

The effect of PON-1 gene polymorphism on the prognosis in the patients with acute organic phosphorus poisoning

作　　者：周宁[1] 姚为学[1] 李志文[1] 梁金明[1] 陈粤明[1] 苏耿[1] 

机构地区：[1]湛江中心人民医院内科,广东湛江524037

出　　处：《广东医学》2015年第11期1673-1675,共3页Guangdong Medical Journal

基　　金：广东省科技计划项目(编号:2010B031600030)

摘　　要：目的探讨对氧磷酶1(PON-1)基因多态性与急性有机磷中毒患者病情的影响。方法 140例急性有机磷中毒患者,经PCR检测基因多态性并分为3组,对比3种基因型患者的血清胆碱酯酶活性、对氧磷酶活性、呼吸衰竭发生率、住院时间。结果在急性有机磷中毒的患者中,PON-1基因型为Q/Q患者呼吸衰竭的发生率比Q/R及R/R型高;PON-1基因型为Q/Q患者的血清胆碱酯酶和PON-1活性比Q/R及R/R型低,住院时间也较Q/R及R/R型长,差异有统计学意义(P<0.05)。结论 PON-1的基因多态性通过影响PON-1的活性,影响急性有机磷中毒患者对毒物的降解,从而影响到患者的病情。可以通过检测PON-1的基因多态性及PON-1的活性来判断患者病情和预后。Objective To investigate the effect of paraoxonase 1 （ PON-1） gene polymorphism on the prognosis in patients with acute organic phosphorus poisoning .Methods A total of 140 cases of acute organic phosphorus poison-ing treated were study and divided into 3 groups according to gene polymorphism of PON -1 using PCR.The serum cho-linesterase activity , paraoxonase activity , respiratory failure rate and hospital stay were compared .Results In the pa-tients with acute organic phosphorus poisoning , the incidence of respiratory failure was significantly higher in patients with Q/Q genotype than those of Q/R and R/R types;with significantly lower activity of PON -1 and serum cholinesterase and longer hospital stay （P＆lt;0.05）.Conclusion The PON-1 gene polymorphism affects the condition of patients with acute organic phosphorus poisoning by influencing the activity of PON -1, thus affecting toxic degradation .The gene polymor-phism detection of PON-1 and the activity of PON-1 can be used to judge the severity and prognosis of patients .

关 键 词：有机磷农药 中毒 对氧磷酶 基因多态性 

分 类 号：R595.4[医药卫生—内科学]