血清降钙素原检测在恶性肿瘤患者感染诊断中的应用评价  

Value of detection of procalcitonin in diagnosis of infections in patients with malignant tumors

作　　者：何国强[1] 张和平[1] 党元娜[1] 

机构地区：[1]河南省人民医院中医科,河南郑州450003

出　　处：《中华医院感染学杂志》2015年第14期3135-3137,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生厅科研基金资助项目(2011020153)

摘　　要：目的对血清降钙素原（PCT）检测在恶性肿瘤患者感染诊断中的应用价值展开研究分析,旨在提高对恶性肿瘤患者感染的诊断能力。方法随机选取2011年9月-2013年9月医院接收救治的100例恶性肿瘤患者,将其分成感染组和对照组,50例发生感染的患者为感染组,50例未发生感染的患者为对照组,两组患者采集静脉血采用荧光免疫分析法进行检测,检测血清中降钙素原浓度,将收集结果进行比较,对诊断资料与手术病理学资料进行回顾性分析。结果 PCT浓度感染组为（18.31±22.13）ng/ml、对照组为（0.29±0.15）ng/ml,感染组PCT水平显著高于对照组,差异有统计学意义（P〈0.01）;感染组患者PCT〈0.5ng/ml有4例、0.5-2.0ng/ml10例、2.0-10.0ng/ml 20例、〉10.0ng/ml 16例,检测呈阳性患者46例,阳性率92.0%,对照组患者PCT〈0.5ng/ml 48例、0.5-2.0ng/ml 2例、PCT检测呈阳性患者2例,阳性率4.0%,感染组PCT检测阳性率显著高于对照组,数据差异有统计学意义（P〈0.01）。结论 PCT可作为早期识别恶性肿瘤患者感染及其严重程度的重要实验室指标,PCT检测对早期诊断、预后评估具有十分重要的临床意义。OBJECTIVE To study the value of detection of procalcitonin（PCT）in diagnosis of infections in the patients with malignant tumor so as to improve the ability of diagnosis of infections in the patients with malignant tumors.METHODS A total of 100 patients with malignant tumors who were treated in the hospital from Sep 2011 to Sep 2013 were enrolled in the study and divided into the infection group and the control group by using randomized single-blind method;totally 50 patients with infections were assigned as the infection group,and 50 patients without infections were set as the control group.The venous blood specimens were collected from the two groups of patients and were detected by using fluorescence immunoassay,the concentrations of serum procalcitonin were determined,the results were compared,and the diagnosis data and pathological data were retrospectively analyzed.RESULTS The concentration of PCT of the infection group was（18.31±22.13）ng/ml,significantly higher than（0.29±0.15）ng/ml of the control group（P〈0.01）.There were 4cases with the concentration of PCT less than 0.5ng/ml,10 cases with the concentration of PCT ranging from 0.5to 2.0ng/ml,20 cases with the concentration of PCT ranging from 2.0to 10.0ng/ml,and 16 cases with the concentration of PCT more than 10.0ng/ml in the infection group,totally 46 cases were tested positive for PCT,with the positive rate of 92.0%;there were 48 cases with the concentration of PCT less than 0.5ng/ml and 2cases with the concentration of PCT ranging from 0.5to 2.0ng/ml in the control group,and 2cases were tested positive for PCT,with the positive rate of4.0%;the positive rate of PCT was significantly higher in the infection group than in the control group（P〈0.01）.CONCLUSIONThe PCT can be served as an important laboratory indicator for early diagnosis of infections and evaluation of the severity of the patients with malignant tumors,and it has great clinical significance to the early diagnosis and evaluation of prognosis.

关 键 词：血清降钙素原 恶性肿瘤 感染诊断 应用价值 

分 类 号：R446[医药卫生—诊断学]