中西医结合治疗慢性胃炎患者幽门螺杆菌感染的疗效观察  

Clinical effect of integrated traditional Chinese medicine and western medicine on treatment of Helicobacter pylori infection in patients with chronic gastritis

作　　者：王元英[1] 佘久宁 周习武 马志强 朱敏 

机构地区：[1]湖北省新华医院综合门诊,湖北武汉430015 [2]武汉市第五医院中医内科,湖北武汉430015 [3]武汉市第五医院中医消化内科,湖北武汉430015 [4]武汉市第五医院中医胃镜室,湖北武汉430015

出　　处：《中华医院感染学杂志》2015年第14期3196-3198,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅医学科研基金资助项目(JX2B59);湖北省医学高等专科学校科研基金资助项目(2012ZB013)

摘　　要：目的观察中医辨证施治结合西医治疗慢性胃炎患者幽门螺杆菌感染的临床效果,为临床治疗提供参考依据。方法选择医院2012年3月-2014年9月收治的216例慢性胃炎患者幽门螺杆菌感染为研究对象,随机分为观察组和对照组,各108例,观察组给予中医辨证施治结合西医三联疗法治疗,对照组仅给予西医三联疗法治疗,对比分析两组患者幽门螺杆菌根除率、慢性胃炎治疗效果、不良反应及复发率。结果患者幽门螺杆菌根除率观察组为91.7%,明显高于对照组患者的79.6%,差异有统计学意义(χ2=6.365,P<0.05);临床治疗总有效率观察组为96.3%,明显高于对照组的88.0%,差异有统计学意义(χ2=5.172,P<0.05);幽门螺杆菌感染复发率观察组为4.6%,明显低于对照组患者的12.0%,差异有统计学意义(χ2=3.879,P<0.05)。结论相比单纯西医三联疗法,中医辨证施治结合西医治疗慢性胃炎患者幽门螺杆菌感染的临床疗效更好,复发率低,安全性高,值得临床应用。OBJECTIVE To observe the clinical effect of integrated traditional Chinese medicine and western medicine on treatment of the chronic gastritis patients with Helicobacter pylori infection so as to provide guidance for clinical treatment.METHODS A total of 216 chronic gastritis patients with H.pyloriinfection who were treated in the hospital from Mar 2012 to Sep 2014 were recruited as the study objects and randomly divided into the observation group and the control group,with 108 cases in each.The observation group was treated with traditional Chinese medicine syndrome differentiation combined with western medicine triple therapy,while the control group was only given western medicine triple therapy.The eradication rate of H.pylori,therapeutic effect,adverse reactions,and recurrence rate were observed and compared between the two groups.RESULTS The eradication rate of H.pylori of the observation group was 91.7%,significantly higher than 79.6% of the control group（χ2=6.365,P〈0.05）.The total effective rate of clinical treatment of the observation group was 96.3%,significantly higher than 88.0% of the control group（χ2=5.172,P〈0.05）.The recurrent rate of H.pylori infection of the observation group was 4.6%,significantly lower than 12.0% of the control group（χ2=3.879,P〈0.05）.CONCLUSION As compared with single western medicine triple therapy,the traditional Chinese medicine syndrome differentiation combined with western medicine triple therapy can achieve more significant clinical effect on treatment of the chronic gastritis patients with H.pylori infection,with the recurrent rate low,the safety high,and it is worthy to be promoted in the hospital.

关 键 词：中西医结合 慢性胃炎 幽门螺杆菌 感染 

分 类 号：R378[医药卫生—病原生物学]