中枢神经系统脱髓鞘疾病与肺炎衣原体感染的相关性研究  

Correlation between central nervous system demyelinating disease and Chlamydia pneumoniae infection

作　　者：许晓辉[1] 马聪敏[1] 韩月珍[1] 

机构地区：[1]郑州大学附属洛阳中心医院神经内科,河南洛阳471009

出　　处：《中华医院感染学杂志》2015年第14期3243-3245,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生厅重点规划基金资助项目(HW-2012B-019)

摘　　要：目的探讨中枢神经系统脱髓鞘疾病与院内肺炎衣原体感染的相关性,为临床诊断治疗提供依据。方法收集2010年5月-2014年3月住院的95例中枢神经系统脱髓鞘疾病患者作为观察组,选择同期住院的87例非中枢神经系统脱髓鞘疾病患者作为对照组,采集其脑脊液标本检测肺炎衣原体特异性抗体(IgA、IgG),对比分析两组患者IgA、IgG阳性率,采用SPSS19.0统计软件进行处理分析。结果对照组男性、女性IgG阳性率分别为48.78%、52.17%,对照组男性、女性IgA阳性率分别为21.95%、17.39%,两组患者性别间比较差异均无统计学意义;观察组IgA阳性率64.21%显著高于对照组IgA阳性率26.44%,组间差异有统计学意义(P<0.05);观察组IgG阳性率67.37%,显著高于对照组IgG阳性率36.78%,差异有统计学意义(P<0.05);观察组男性、女性IgA阳性率分别为60.47%、63.46%,比较差异无统计学意义;观察组男性、女性IgG阳性率分别为67.44%、61.54%,比较差异无统计学意义。结论中枢神经系统脱髓鞘疾病的发生与肺炎衣原体感染具有一定的相关性,肺炎衣原体指标IgA、IgG有可能成为中枢神经系统脱髓鞘疾病诊断的重要参考指标。OBJECTIVE To explore the correlation between the central nervous system demyelinating disease and hospital-acquired Chlamydia pneumoniae infections so as to provide guidance for clinical diagnosis and treatment.METHODS Totally 95 patients with central nervous system demyelinating disease who were hospitalized from May2010 to Mar 2014 were chosen as the observation group,meanwhile,87 hospitalized patients with non-central nervous system demyelinating disease were set as the control group.The cerebrospinal fluid specimens were collected for the detection of specific antibodies（IgA,IgG）of C.pneumoniae,the positive rates of IgA and IgG were observed and compared between the two groups of patients,and the statistical analysis was performed with the use of SPSS 19.0software.RESULTS In the control group,the positive rate of IgG of the male patients was48.78%,the female patients 52.17%,the positive rate of IgA of the male patients was 21.95%,the female patients 17.39%.The positive rate of IgA of the observation group was 64.21%,significantly higher than 26.44%of the control group（P〈0.05）;the positive rate of IgG of the observation group was 67.37%,significantly higher than 36.78% of the control group（P〈0.05）.In the observation group,the positive rate of IgA of the male patients was 60.47%,the female patients 63.46%,and there was no significant difference;the positive rate of IgG of the male patients was 67.44%,the female patients 61.54%,and there was no significant difference.CONCLUSIONThe occurrence of central nervous system demyelinating disease is,to a certain degree,associated with the C.pneumoniaeinfections.The IgA and IgG of the C.pneumoniae are expected to serve as the important reference indicators for diagnosis of the central nervous system demyelinating disease.

关 键 词：中枢神经系统脱髓鞘疾病 肺炎衣原体 相关性 

分 类 号：R181.32[医药卫生—流行病学]