妇产科患者多药耐药菌感染的临床研究  

Clinical study of multidrug-resistant bacteria infections in patients of department of gynecology and obstetrics

作　　者：杨欣慰 崔华英 陈贤梅 

机构地区：[1]宜昌市第二人民医院妇产科,湖北宜昌443000

出　　处：《中华医院感染学杂志》2015年第14期3311-3313,共3页Chinese Journal of Nosocomiology

基　　金：湖北省科技攻关基金资助项目(2005A304B09)

摘　　要：目的探讨妇产科患者多药耐药菌感染的病原菌分布及感染相关因素等,便于加强监测和预防,减少甚至避免多药耐药菌感染的发生。方法将2009年10月-2013年10月妇产科58例发生多药耐药菌感染患者作为研究对象,采集标本进行细菌培养及药敏试验,对病原菌与患者年龄、住院时间、抗菌药物种类及使用时间、侵入性操作等感染相关因素进行统计分析。结果感染部位主要为呼吸道、泌尿道感染及手术切口感染为主,分别占46.55%、22.41%及18.97%;多药耐药菌感染患者共检出病原菌62株,主要为金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌和肺炎克雷伯菌,分别占40.32%、16.13%、11.29%、14.52%。结论抗菌药物联合使用和长期使用是引起多药耐药菌感染的主要因素,加强多药耐药菌感染的管理与控制、严格无菌操作、合理使用抗菌药物预防是控制多药耐药菌感染的有效手段。OBJECTIVE To explore the distribution of multidrug-resistant pathogens causing infections in the patients of department of gynecology and obstetrics and analyze the related factors for the infections so as to strengthen the monitoring and prevention and reduce or even avoid the incidence of multidrug-resistant bacteria infections.METHODS A total of 58 patients with multidrug-resistant bacteria infections who were treated in the department of gynecology and obstetrics from Oct 2009 to Oct 2013 were recruited as the study objects,then the specimens were collected for bacterial culture,the drug susceptibility testing was performed,and the related factors for the infections,including the age,length of hospital stay,types of antibiotics,time of use of antibiotics,and invasive operations,were statistically analyzed.RESULTS Of the patients with infections,46.55% had the respiratory tract infections,22.41% had the urinary tract infections,and 18.97% had the surgical incision infections.Totally 62 strains of pathogens have been isolated from the patients with multidrug-resistant bacteria infections;Staphylococcus aureus,Pseudomonas aeruginosa,Escherichia coli,and Klebsiella pneumoniae were dominant among the pathogens,accounting for 40.32%,16.13%,11.29%,and 14.52%,respectively.CONCLUSION The combined use of antibiotics and long-term use of antibiotics are the leading causes of the multidrug-resistant bacteria infections.It is an effective way to strengthen the control of multidrug-resistant bacteria infections,implement strict aseptic operations,and reasonably use antibiotics for prevention so as to control the multidrug-resistant bacteria infections.

关 键 词：多药耐药菌 妇产科 易感因素 病原菌 

分 类 号：R181.32[医药卫生—流行病学]