妇科肿瘤患者医院感染病原菌与耐药性研究  

Distribution and drug resistance of pathogens causing nosocomial infections in patients with gynecologic cancer

作　　者：安强[1] 杨炳[1] 林振江[1] 王明阳[1] 向加林[1] 黎兵[1] 

机构地区：[1]贵州省遵义医学院附属医院妇科,贵州遵义563003

出　　处：《中华医院感染学杂志》2015年第14期3317-3319,共3页Chinese Journal of Nosocomiology

基　　金：贵州省科技厅联合基金资助项目(黔科合J字Lkz[2011]20)

摘　　要：目的探讨妇科癌症患者医院感染病原菌与耐药性,为临床治疗提供科学依据。方法回顾性分析2010年1月-2014年12月500例妇科癌症患者的临床资料,分析发生感染的病原菌种类分布及耐药性,数据均采用SPSS 17.0软件进行统计处理。结果发生医院感染30例,感染率6.00%;检出37株病原菌,以革兰阴性菌为主占67.57%,革兰阳性菌占24.32%,真菌占8.11%;铜绿假胞菌对米诺环素及美罗培南较敏感,耐药率均为11.11%,对头孢他啶及哌拉西林耐药率较高,分别为77.78%和88.89%;金黄色葡萄球菌对万古霉素、利奈唑胺及替考拉宁较敏感,耐药率均为0;假丝酵母菌属对氟胞嘧啶、两性霉素B、酮康唑以及制霉菌素耐药率均为0,对氟康唑耐药率为100.00%。结论妇科癌症患者医院感染病原菌主要以革兰阴性菌为主,临床治疗要根据药敏结果,选择合理的抗菌药物,有效的提升临床疗效。OBJECTIVE To explore the distribution and drug resistance of pathogens causing nosocomial infections in the patients with gynecologic cancer so as to provide scientific basis for clinical treatment.METHODS The clinical data of 500 patients with gynecologic cancer who were treated from Jan 2010 to Dec 2014 were retrospectively analyzed,then the distribution and drug resistance of the pathogens causing infections were observed,and the statistical analysis of data was performed with the use of SPSS 17.0software.RESULTS The nosocomial infections occurred in 30 cases with the infection rate of 6.00%.A total of 37 strains of pathogens have been isolated,of which 67.57% were gram-negative bacteria,24.32% were gram-positive bacteria,and 8.11% were fungi.The drug resistance rates of Pseudomonas aeruginosa to minocycline and meropenem were 11.11%,and the drug resistance rates to ceftazidime and piperacillin were 77.78% and 88.89%,respectively.The drug resistance rates of Staphylococcus aureus to vancomycin,linezolid,and teicoplanin were 0.The drug resistance rates of Candida spp to flucytosine,amphotericin B,ketoconazole,and nystatin were 0,and the drug resistance rate to fluconazole was100.00%.CONCLUSIONThe gram-negative bacteria are the predominant pathogens causing the nosocomial infections in the patients with gynecologic cancer.It is necessary for the hospital to reasonably use antibiotics based on the results of the drug susceptibility testing so as to effectively improve the clinical efficacy.

关 键 词：妇科癌症 医院感染 病原菌 耐药性 

分 类 号：R181.32[医药卫生—流行病学]