不同方法治疗反复呼吸道感染患儿的临床疗效对比  

Clinical efficacies of different therapies in treatment of children with recurrent respiratory tract infections

作　　者：刘芳[1] 黄荣华[2] 王淑莲[3] 

机构地区：[1]汉川市人民医院儿科,湖北汉川432300 [2]汉川市人民医院眼科,湖北汉川432300 [3]汉川市人民医院肿瘤科,湖北汉川432300

出　　处：《中华医院感染学杂志》2015年第14期3328-3330,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生厅基金资助项目(WJ01564)

摘　　要：目的分析应用抗菌药物和抗菌药物结合免疫调节方法治疗儿童反复呼吸道感染的临床疗效,为合理治疗提供依据。方法选取2011年2月-2012年5月在医院儿科门诊及住院的80例反复呼吸道感染患儿,随机将其分为A组40例以抗菌药物结合免疫调节治疗和B组40例只应用抗菌药物治疗,观察记录两组患儿的治疗效果、临床症状持续时间以及治疗前后免疫学参数。结果反复呼吸道感染患儿治疗总有效率A组为97.5%、B组为85.0%,A组患儿的治疗效果显著优于B组,差异有统计学意义(P<0.05);A组患儿咳嗽缓解及肺部啰音消失时间明显短于B组,治疗后A组呼吸道感染发作次数及发病天数明显低于B组,两组结果比较差异有统计学意义(P<0.05);A组患儿的IgG提高程度显著高于B组,A组患儿CD4+及CD4+/C8+比值升高水平及CD8+下降程度与B组比较差异均有统计学意义(P<0.05)。结论抗菌药物结合免疫调节方法治疗反复呼吸道感染的疗效优于单纯应用抗菌药物治疗,值得临床推广使用。OBJECTIVE To observe the clinical efficacies of the antibiotics therapy and antibiotics therapy combined with immunomodulation in treatment of the children with recurrent respiratory tract infections so as to provide guidance for reasonable treatment.METHODS A total of 80 children with recurrent respiratory tract infections who were treated in the pediatrics department and hospitalized from Feb 2011 to May 2012 were enrolled in the study and randomly divided into the group A with 40 cases and the group B with 40 cases.The group A was treated with antibiotics combined with immunomodulation,while the group A was only given the antibiotics therapy.The curative effects,durations of clinical symptoms,and immunological parameters before and after the treatments were observed and compared between the two groups of children.RESULTS The total effective rate of treatment of the children with recurrent respiratory tract infections was 97.5%in the group A,85.0%in the group B;the curative effect of the group A was significantly better than that of the group B,and there was statistically significant difference（P〈0.05）。The time of relief of count and the time of disappearance of pulmonary rales of the group A were significantly shorter than those of the group B;after the treatment,the frequency of attack of respiratory tract infections and the onset duration of the group A were significantly less than those of the group B,and there was statistically significant difference（P〈0.05）.The increase of IgG level of the group A was significantly higher than that of the group B,and there was statistically significant difference in the increase of CD4＋level,the ratio of CD4＋to CD8＋,or decrease of CD8＋level between the group A and the group B（P〈0.05）.CONCLUSION The clinical efficacy of the antibiotics therapy combined with immunomodulation is superior to the single antibiotics therapy in the treatment of the recurrent respiratory tract infections,and it is worthy to be promoted in the hospital.

关 键 词：患儿 反复呼吸道感染 抗菌药物 免疫调节 CD4+ CD8+ 

分 类 号：R563.1[医药卫生—呼吸系统]