肾小球基底膜中胶原的合成、降解与糖尿病肾病  

Synthesis and degradation of collagen in glomerular basement membrane and their associations with diabetic nephropathy

作　　者：任惠珠[1] 王珊珊[1] 郑妙艳[1] 单春艳[1] 

机构地区：[1]天津医科大学代谢病医院内分泌研究所、卫生部激素与发育重点实验室,300070

出　　处：《国际内分泌代谢杂志》2015年第4期252-254,共3页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（81473472）

摘　　要：糖尿病肾病是终末期肾病的主要原因，发病机制复杂。肾小球基底膜增厚及系膜区细胞外基质增生是主要的病理特点，胶原合成增多、降解减少是肾脏病理改变的主要原因。研究肾小球滤过屏障的生理功能与损伤机制，对深入了解糖尿病肾病的发生、发展尤为重要。Diabetic nephropathy,with a complicated pathogenesis, has become the major cause of end stage renal disease. The thickening of glomerular basement membrane and hyperplasia of mesangial area of extracellular matrix are the main pathological features. Increased synthesis and decreased degradation of collagen are major causes of renal pathological changes. Researches of the physiological function and the injury mechanism of glomerular filtration barrier are particularly important for further understanding of the occurrence and develooment of diabetic neohrooathy.

关 键 词：肾小球基底膜 胶原 合成 降解 糖尿病肾病 

分 类 号：R692.3[医药卫生—泌尿科学]