二甲双胍在甲状腺疾病治疗中的作用  

Roles of metformin in the treatment of thyroid diseases

作　　者：杨成会[1] 缪珩[1] 

机构地区：[1]南京医科大学第二附属医院内分泌科,210000

出　　处：《国际内分泌代谢杂志》2015年第4期255-257,263,共4页International Journal of Endocrinology and Metabolism

摘　　要：二甲双胍是治疗糖尿病较为安全、有效的一线药物之一。近年来，有研究报道糖尿病患者常伴有甲状腺功能减退症及甲状腺结节增生，其甲状腺癌的发病率也明显增加。而服用二甲双胍可以改善胰岛素抵抗、减轻高胰岛素血症，降低促甲状腺激素（TSH）水平，减少甲状腺结节的增生，并阻滞细胞周期进程，抑制甲状腺癌细胞的增殖，协同增强化学治疗药物的敏感性。因此，二甲双胍有可能在辅助治疗甲状腺疾病中发挥重要角色。Metformin,the first-line medicine for the treatment of diabetes,is generally considered to be a relatively safe and effective drug. In recent years, some studies have reported that diabetic patients are often accompanied by hypothyroidism, thyroid nodular hyperplasia, and the rising incidence of thyroid cancer, while taking metformin can improve insulin resistance, reduce hyperinsulinemia, decrease thyroid stimulating hormone （TSH） levels, suppress the hyperplasia of thyroid nodules, block the cell cycle progression and inhibit the proliferation of thyroid cancer cells,as well as synergistically enhance the sensitivity to chemotherapeutic drugs. Therefore, mefformin may play an important role in the adjuvant treatment of thyroid diseases.

关 键 词：二甲双胍 促甲状腺激素 甲状腺结节 甲状腺癌 

分 类 号：R961[医药卫生—药理学]