疏肝益肾汤联合枸橼酸氯米芬治疗无排卵性不孕症45例  

Clinical Research on Combined Shugan Yishen Decoction with Clomiphene in Treatment of Anovulatory Infertility in 45 Cases

作　　者：张华军[1] 赵爱华[2] 

机构地区：[1]北京军区总医院二六三临床部,北京101100 [2]中国人民解放军总参谋部总医院,北京100091

出　　处：《中国实验方剂学杂志》2015年第14期165-168,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:探讨疏肝益肾汤联合枸橼酸氯米芬治疗无排卵性不孕症的临床疗效及对性激素的影响。方法:90例无排卵性不孕症就诊患者采用随机按数字表法分为治疗组和对照组各45例。治疗组给予疏肝益肾汤联合枸橼酸氯米芬治疗;对照组给予枸橼酸氯米芬治疗。两组疗程均为3个月经周期。采用B超监测卵泡发育情况,统计排卵率、妊娠率和流产率;酶联免疫法测定血清睾酮(T),泌乳素(PRL),促黄体生成素(LH),雌二醇(E2),卵泡刺激素(FSH)的水平。结果:治疗后治疗组的排卵率、妊娠率高于对照组(P<0.05),流产率低于对照组(P<0.05);治疗后治疗组的月经不调例数低于对照组(P<0.05),月经量少、色黯例数低于对照组(P<0.01);治疗后治疗组的患者子宫内膜厚度显著高于对照组(P<0.05);治疗后治疗组的睾酮、泌乳素、黄体生成素和卵泡刺激素水平低于对照组(P<0.05);两组雌二醇水平均降低,组间差异无统计学意义。结论:疏肝益肾汤联合枸橼酸氯米芬可温肾助阳,疏肝调经,能提高无排卵性不孕症患者的妊娠率,临床疗效优于单纯的枸橼酸氯米芬治疗。Objective： Explore the Clinical efficacy of combined Soothing liver and Kidney decoction with Clomiphene in the treatment of anovulatory infertility and theeffect of sex hormonesete. Method： Ninety cases of anovulalory infertility were divided into treatment group and control group by using random number method. The treatment group received the treatment of Shugan Yishen recipe combined with clomiphene ; the control group was treated with clomiphene treatment only. The period of the two groups was 3 menstrual cycles. Use B-ultrasonic wave to monitor the development of ovarian follicles, count the ovulation rate, pregnancy rate and miscarriage rate. Enzyme-linked immuno sorbent assay （ELISA） measured the levels of testosterone （T） , prolactin （PRL） , estradiol （ E2 ） , luteinizing hormone （LH） and follicle-stimulating hormone （ FSH）. Result： The ovulation rate and pregnancy rate of treatment group were higher than control group, while abnormal menstruation cases and miscarriage rate were lower than control group after treatment. Endometrial thickness were significantly improved in the treatment group. The levels of LH, FSH, T and PRL in treatment group were lower than control group＇. Two estradiol levels were reduced, there were no significant difference between the groups. Conclusion： Shugan Yishen recipe can responsiveness of the penis in kidney, regulate the liver and the menstrual function to increase the pregnancy rate and it was better than clomipheneelinically.

关 键 词：无排卵性不孕症 疏肝益肾汤 枸橼酸氯米芬 妊娠 

分 类 号：R287[医药卫生—中药学]