糖脉康颗粒对2型糖尿病患者血糖水平的影响  

Tangmaikang Particles to Glucose Fluctuation of Patients with Type Two Diabetes Mellitus

作　　者：胡嫚丽[1] 邓红艳[1] 符杰[1] 廖丽娅[1] 

机构地区：[1]华中科技大学同济医学院附属普爱医院,武汉430033

出　　处：《中国实验方剂学杂志》2015年第14期173-176,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察糖脉康颗粒对2型糖尿病患者血糖、血脂水平及患者胰岛功能的影响。方法:2012年1月至2014年6月本院内分泌科收治的230例2型糖尿病患者,采用随机数字表法分为对照组和观察组,对照组予口服二甲双胍片治疗,观察组在对照组治疗的基础上加服糖脉康颗粒,总治疗时间为8周,比较两组患者治疗前后的空腹血糖(FBG),餐后2 h血糖(2h PBG)及糖化血红蛋白(Hb A1c);72 h动态血糖数据,血糖水平的标准差(SDBG),平均血糖波动幅度(MAGE),日渐血糖平均绝对差(MODD)及餐后血糖波动均值(MPPGE),并计算胰岛抵抗指数(HOMA-IR),胰岛β细胞分泌功能指数(HOMA-IS)和胰岛素敏感指数(ISI);血清甘油三酯(TG),总胆固醇(TC),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)。结果:治疗后两组患者SDBG,MAGE,MODD,MPPGE,HOMA-IR FBG,2 h PBG,Hb A1c,TG,TC,LDL-C均较治疗前有所下降,观察组下降幅度更大(P<0.05)。HOMA-IS和ISI较治疗前有所升高,观察组升高更明显(P<0.05)。结论:糖脉康颗粒有助于糖尿病患者血糖稳定,对保存患者胰岛功能改善血脂代谢有一定帮助,值得临床应用。Objective： The aim of this study was to siscuss the influence of Tangmaikang particles on glucose fluctuation and impact on oxidative stress, and the function of vascular endothelium in treating type-two diabetes mellitus （T2DM）. Method： Two hundred and thirty patients with T2DM were randomly divided into control group and observation group by random number table. Patients in control group received repaglinide tablets. Based on the treatment of control group, patients in observation group were added Tangmaikang particles. Before and after treatment, continuous glucoses including standard deviation of blood glucose level （SDBG）, mean amplitude of glycemic excursions （ MAGE）, mean of daily differences （MODD）, and mean postprandial glucose excursion （MPPGE） were monitored; and fasting blood-glucose （FBG）, fasting insulin （FINS）, two hours＇ postprandial blood glucose （2 hPBG） and glycosylated hemoglobin （HbA1 c） were detected, and indexes of homeostasis model assessment of insulin resistance （HOMA-IR） , secretion function of pancreas islet B cell and insulin sensitivity （ISI） were calculated. The serum triglyceride （TC）, total cholesterol （TC）, high density lipoprotein （HDL-C） , and low density lipoprotein （LDL-C） were measured. Result： After treatment, indexes of SDBG, MACE, MODD, MPPCE, HOMA-IR FBC, 2 hPBG, HbAlc, TG, TC and LDL-C in observation group were all lower than those in control group, but the indexes of HOMA-IS and IS1 were higher than those in control group （P 〈 0.05 ）. Conclusion ： Tangmaikang particles can reduce blood glucose of patients with T2DM, keep the stability of blood glucose, regulate the intraday glucose fluctuation, and improve blood lipid metabolism, which is worthy of clinical application.

关 键 词：2型糖尿病 血糖波动 糖脉康颗粒 胰岛抵抗 胰岛敏感性 

分 类 号：R287.6[医药卫生—中药学]