银黄制剂的研究进展  

Research Progress of Yinhuang Preparation

作　　者：周淑芳 刘晓妹[2] 于聪 崔龙 高进[1,2] 

机构地区：[1]丽珠医药集团股份有限公司,国家中药现代化工程技术研究中心,广东珠海519020 [2]澳门科技大学中药质量研究国家重点实验室,中国澳门 [3]珠海市第二人民医院,广东珠海519020

出　　处：《中国实验方剂学杂志》2015年第14期222-225,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广东省粤港关键领域重点突破项目(2008A030600007);珠海市香洲区科技计划项目(ZC81210)

摘　　要：简述了临床上广泛应用的抗感染中药制剂银黄制剂在制备工艺、质量标准研究和临床应用等方面的最新研究进展。分别概括了口服液、颗粒剂、胶囊剂、片剂、注射剂等常规制剂与口腔崩解片、滴丸、分散片、气雾剂、软胶囊、泡腾片、液体胶囊等新剂型的制备工艺。阐述银黄制剂质量标准研究中采用较为先进的技术,包括红外光谱法、毛细管电泳法、指纹图谱、液质联用和一测多评法。介绍银黄制剂在咽喉疾病、上呼吸道感染和神经痛及疱疹等疾病的临床应用。银黄制剂是一类药味较少、质量控制规范、临床疗效确切的中药制剂,具有很大的市场潜力,应进一步深入研究银黄制剂的制备工艺、质量标准以及药物代谢机制等,为该制剂的现代化和产业化寻找突破口。This article briefly introduces the latest research progress on preparation technology, quality standard and clinical application of Yinhuang preparation which is widespreadly clinical used Chinese patent medicine. It summarizes preparation technology of Yinhuang traditional preparation including oral liquid, granules, capsules, injection and new preparation including mouth dissolve tablets, dripping pills, dispersible tablets, aerosol, soft capsules, effervescent tablets, liquid capsules. This article also demonstrates related advanced technology of research on Yinhuang preparation＇s quality standard, such as infrared spectroscopy, capillary electrophoresis, fingerprint, LC-MS and quantitative analysis of multi-components by single-marker. Besides, it introduces Yinhuang preparation＇s clinical application on throat disease, upper respiratory tract infection, neuralgia and herpes. Yinhuang preparation is a kind of Chinese patent medicine with two simple herbs, good quality controlled standard and clinical efficacy. We should strengthen further research on preparation technology, quality standard and metabolic mechanism to search for breakthrough of modernization of Chinese materia medica and internationalization.

关 键 词：银黄制剂 制备工艺 质量标准 临床应用 

分 类 号：R283.6[医药卫生—中药学] R284.1[医药卫生—中医学]