手性配体金属配合物催化的Aza-Henry反应  

Asymmetric Aza-Henry Reactions Promoted by Chiral Catalysts

作　　者：张瑞[1] 张永丽[1] 李兴[1] 常宏宏[1] 高文超[1] 魏文珑[1] 

机构地区：[1]太原理工大学化学化工学院,山西太原030024

出　　处：《化学试剂》2015年第7期577-584,共8页Chemical Reagents

基　　金：山西省自然科学基金资助项目(2012021007-2;2011011010-2)

摘　　要：手性β-硝基胺类化合物是非常重要的有机合成中间体,被广泛应用于药物和天然产物的合成中,不对称Aza-Henry反应是合成该类化合物最有效的方法之一,近年来已取得了重要进展。到目前为止,该类反应中使用的催化剂主要是由金属Cu、Ni和Zn等分别与手性配体配合而形成的配合物,而且在这些催化剂作用下大部分反应都取得了较好的催化活性和对映选择性,就各类金属与手性配体形成的配合物催化剂在不对称Aza-Henry反应中的应用进行综述。Chiral β-nitro amines are very important intermediates in organic synthesis which are widely used in pharmaceutical and natural products. The asymmetric Aza-Henry reaction is one of the most effective ways for the synthesis of these compounds and important progress has been made in recent years. So far,the catalysts utilized in these reactions are mainly complexes made of metal Cu,Ni,Zn,etc. and some chiral ligands. Good catalytic activity and enantioselectivity have been obtained about many reactions. The work reviewed the application of these catalysts in the asymmetric Aza-Henry reactions.

关 键 词：Aza-Henry反应 不对称催化 配合物 手性 

分 类 号：O627[理学—有机化学]