儿童特发性血小板减少性紫癜淋巴细胞亚群变化  

Change of lymphocyte subsets in children with idiopathic thrombocytopenic purpura

作　　者：张兰芳[1] 胡正[1] 山浩明[1] 

机构地区：[1]南京医科大学附属南京儿童医院儿科研究所,江苏南京210008

出　　处：《蚌埠医学院学报》2015年第6期798-800,共3页Journal of Bengbu Medical College

摘　　要：目的:儿童分析特发性血小板减少性紫癜(ITP)外周血淋巴细胞亚群的变化。方法:应用流式细胞术,分别检测85例ITP患儿(ITP组)和32名健康体检儿童(对照组)淋巴细胞亚群。结果:与对照组相比,ITP组患儿外周血CD3+和CD4+细胞数量减少,CD4+/CD8+比值下降(P<0.01);CD8+细胞与对照组差异无意义(P>0.05)。CD19+细胞较对照组明显增多,CD16+CD56+细胞较对照组减少(P<0.01)。结论:ITP患儿淋巴细胞亚群与正常儿童存在差异,淋巴细胞亚群紊乱是儿童ITP发生的免疫机制之一。Objective：To explore the changes of lymphocyte subsets in children with idiopathic thrombocytopenic purpura （ITP）. Methods： The changes of lymphocyte subsets in 85 patients with ITP and 33 heathy people were detected by flow cytometry. Results： The percentages of CD3 ＋ and CIM＋ and the ratio of CIM/CD8 in ITP group were lower than those in control group（ P 〈 0.01 ）, and the difference of CD8＋ lymphocyte between two groups was not statistically significant （ P 〉 0.05 ）. Compared with the control group, the number of CD19 ＋ and CD16 ＋ CD56 ＋ lymphocytes in ITP group increased and decreased, respectively,the differences of whose between two groups were statistically significant（P 〈 0.01 ）. Conclusions：The disorder of lymphocyte subsets is one of the .immune mechanism of ITP occurrence in children. Correcting disorder will be conducive to the treatment.

关 键 词：紫癜 血小板减少性 T淋巴细胞 B淋巴细胞 自然杀伤细胞 

分 类 号：R554.6[医药卫生—血液循环系统疾病]