辛伐他汀对哮喘急性发作患者血清转化生长因子β1和白介素17水平的影响研究  

Impact of Simvastatin on Serum Levels of TGF-β_1 and IL-17 of Patients with Acute Asthma

作　　者：范春晖[1] 孙书珍 

机构地区：[1]中国石油大学(华东)医院内科,山东省青岛市266580 [2]山东省省立医院儿科

出　　处：《实用心脑肺血管病杂志》2015年第5期36-38,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探讨辛伐他汀对哮喘急性发作患者血清转化生长因子β1(TGF-β1)和白介素17(IL-17)水平的影响,为哮喘的临床防治提供新的治疗选择。方法选择2009年4月—2013年7月在中国石油大学(华东)医院内科住院的哮喘急性发作患者83例,随机分为常规治疗组43例和辛伐他汀组40例。两组患者均给予基础治疗,辛伐他汀组患者在此基础上加用辛伐他汀,均连续治疗7 d。两组患者于治疗前及治疗后第8天进行哮喘控制测试(ACT)评分,检测肺功能〔第一秒用力呼气容积占预计值百分比(FEV1%)、第一秒用力呼吸容积占用力肺活量百分比(FEV1/FVC)〕及血清TGF-β1和IL-17水平,记录辛伐他汀组患者治疗期间不良反应发生情况。结果治疗前后两组患者ACT评分、FEV1%及FEV1/FVC比较,差异均无统计学意义(P>0.05)。治疗前两组患者血清TGF-β1、IL-17水平比较,差异无统计学意义(P>0.05);治疗后辛伐他汀组患者血清TGF-β1、IL-17水平低于对照组(P<0.05)。辛伐他汀组患者中有3例(7.5%)出现轻度腹痛、便秘或胃肠胀气,但未影响继续治疗。结论辛伐他汀能有效降低哮喘急性发作患者血清TGF-β1和IL-17水平,从而减轻气道炎性反应、延缓气道重塑,对哮喘急性发作有一定的治疗作用。Objective To explore the impact of simvastatin on serum levels of TGF - β1 and IL - 17 of patients with acute asthma, to provide new therapeutic options for asthma. Methods From April 2009 to July 2013, a total of 83 in - patients with acute asthma were selected in the Department of Internal Medicine, China University of Petroleum （Huadong） Hospital, and they were randomly divided into control group （n =43） and observation group （n = 40）. Patients of both groups were given basic treatment, and patients of observation group were given extra simvastatin for 7 days. ACT score, lung function index including FEV1% and FEV1/FVC, serum levels of TGF -β1 and IL- 17 were compared between the two groups before treatment and on the eighth day of treatment, and the incidence of adverse reactions of observation group was recorded during treatment. Results No statistically significant differences of ACT score, FEV1% or FEV1/FVC was found between the two groups before or after treatment （ P 〉 0. 05 ）. No statistically significant differences of serum TGF - β0 or IL - 17 level was found between the two groups before treatment （ P 〉 0. 05 ） ; while serum levels of TGF - β1 and IL - 17 of observation group were statistically significantly lower than those of control group （P 〈 0. 05 ）. In observation group, 3 cases occurred mild abdominal pain, constipation or flatulence, without affecting the treatment. Conclusion Simvastatin can effectively reduce the serum levels of TGF -β1 and IL - 17, relieve the airway inflammatory reaction and delay process of airway remodeling, has certain therapeutic effect on acute asthma.

关 键 词：哮喘 辛伐他汀 转化生长因子Β1 白介素17 

分 类 号：R562.25[医药卫生—呼吸系统]