探讨夜针当日血清SHBG水平与取卵时间、胚胎质量及妊娠结局相关性分析  

Explore the needle on the night serum SHBG levels and correlation analysis between egg embryo quality and outcome of pregnancy

作　　者：张鑫[1] 刁红录[1] 董毅飞[1] 徐鸿毅[1] 罗清炳[1] 张昌军[1] 

机构地区：[1]湖北医药学院附属人民医院生殖医学中心,湖北十堰420000

出　　处：《中国处方药》2015年第7期8-10,共3页Journal of China Prescription Drug

摘　　要：目的探讨控制性超排卵在夜针当天血清SHBG水平高低与取卵手术时间、胚胎质量及妊娠结局的相关性分析。方法予0.1Gn RHa长方案治疗需要行常规体外受精的不孕患者共1 080个周期的资料,按夜针SHBG浓度分四组比较实验室结果和临床结局。结果四组之间Gn用量、获卵数、E2、T、游离睾酮FAI指数、取卵时间、可利用胚胎数、优质胚胎数差异有统计学意义(P<0.05);SHBG与Gn用量、LH、游离睾酮FAI指数显著负相关,与获卵数、E2、T、取卵时间、可利用胚胎数、优质胚胎数显著正相关;妊娠组与未妊娠组HCG日SHBG和游离睾酮差异均无统计学意义(P>0.05)。结论 HCG日SHBG水平可加长取卵时间,减少Gn用量,增加可利用胚胎数及优质胚胎数,对妊娠结局及游离睾酮FAI指数影响不大。Objective Discussion on controlled ovarian hyperstimulation in night probe the day serum SHBG levels correlated with oocyte and embryo quality and operation time correlation analysis of pregnancy outcomes. Methods Analysis needed with conventional in vitro fertilization treatment for infertility 1 080 cycles of data sharing, the SHBG levels divided into four groups to compare laboratory results and clinical outcomes. Results There were significant differ- ences of Gn consumption, the number of egg, E2, T, index of FAI, ovulation time, the time of taking egg, the number of useful embryo and the number of high quality embryo among the four groups.SHBG had a significant negative correlation with Gn consumption, LH and index of FAI, and had a significant positive correlation with the number of egg, E2, T, the time of taking egg, the number of useful embryo and number of high quality embryo.There were no significant differences of SHBG and free-testoterone which was detected after adding HCG between the pregnancy group and non-pregnancy group.Conclusion Day of the HCG injections, levels of SHBG can lengthen the time of taking eggs, reduce the dosage of Gn, increase the number of useful embryo and high quality embryo. But it can＇ t change pregnancy and the index ofFAL

关 键 词：人绒毛膜促性腺激素 性激素结合球蛋白 GNRH拮抗剂 胚胎移植 

分 类 号：R714.8[医药卫生—妇产科学]