新生儿缺氧缺血性脑病患儿VEGF、CK及CK-BB检测的临床价值  

Clinical value of testing VEGF,CK and CK-BB in diagnosis of neonate hypoxic-ischemic encephalopathy

作　　者：熊维[1] 郑培榆[2] 李晓文[3] 

机构地区：[1]重庆医科大学附一院酉阳医院儿科,重庆市409800 [2]重庆市第九人民医院药剂科,400700 [3]重庆医科大学附属儿童医院新生儿科,400016

出　　处：《中华全科医学》2015年第9期1460-1461,1533,共3页Chinese Journal of General Practice

摘　　要：目的探讨新生儿缺氧缺血性脑病患儿血管内皮生长因子(VEGF)、血清肌酸激酶(CK)、肌酸激酶脑型同工酶(CK-BB)的动态变化及其意义,以期为新生儿缺氧缺血性脑病患儿的早期诊断提供参考依据。方法选取2012年1月—2013年11月间来新生儿科进行住院治疗的102例新生儿缺氧缺血性脑病患儿和30例正常新生儿分别在生后1天内、第3天、第7天采集股静脉血,采用ELISA双抗体夹心法集中检血浆VEGF水平,采用酶联免疫法测定CK、CK-BB水平。结果病例组的患者在出生后第1天、第3天、第7天VEGF、CK及CK-BB的水平均明显高于对照组,差异均有统计学意义(P<0.01)。结论血清VEGF、CK、CK-BB的检测与分析在新生儿缺氧缺血性脑病的早期诊断中具有非常重要的临床意义,早期检验3种指标可以对HIE患儿早期诊断,使患儿能够及时接受有效的临床治疗,从而减少了HIE导致的严重不良预后。Objective To explore the dynamic changes and significance of vascular endothelial growth factor（ VEGF）, se- rum creatine kinase creatine kinase（CK） and brain specific isoenzyme（CK-BB） in the neonates with hypoxic ischemic encephalopathy（ HIE）, and provide reference for the early diagnosis of neonatal HIE. Methods A total of 102 neonates with HIE and 30 normal neonates from January 2012 to November 2013 in our hospital were enrolled and divided into HIE group and control group. The femoral vein blood was prepared on the dl, d3 and d7 after the birth to test the level of VEGF,CKandCK-BB by using ELISA. Results The levels of VEGF,CK and CK-BB on dl ,d3 and d7 in theHIE group were significantly higher than those in the control group, thedifference was statistically significant （ P 〈 0. 01 ） . Conclusion The detection of serum VEGF, CK and CK-BB levels has very important clinical significance in the early di- agnosis of neonatal HIE, theearly test can make sure the neonates receive timely clinical treatment,and reduce the serious undesirable prognosis due to HIE.

关 键 词：新生儿缺氧缺血性脑病 血管内皮生长因子 血清肌酸激酶 肌酸激酶脑型同工酶 

分 类 号：R722.1[医药卫生—儿科]