左炔诺孕酮宫内释放系统对胰岛素样生长因子-1的影响与预防盆腔炎的相关性研究  

Effect of levonorgestrel intrauterine system on IGF-1 and the dependablity study of prevention pelvic inflammatory disease

作　　者：吴晓杰[1] 刘霞[1] 陶跃平 王洁[1] 

机构地区：[1]嘉兴市妇幼保健院妇科,浙江嘉兴314051

出　　处：《中国工程科学》2015年第6期4-7,共4页Strategic Study of CAE

基　　金：浙江省医药卫生科技项目(2010KYB108)

摘　　要：目的:研究左炔诺孕酮宫内释放系统对子宫内膜组织胰岛素样生长因子-1(IGF-1)的影响及预防盆腔炎疗效分析。方法:选取2010―2013年在嘉兴市妇幼保健院行宫腔镜下子宫内膜息肉切除术患者450例进行随机分组,研究组术后子宫内即时放置左炔诺孕酮宫内释放系统,而对照组不予放置。分别对术前及术后6个月子宫内膜组织IGF-1的表达情况进行对比,且随访2年,了解患者盆腔炎发生情况。结果:所有手术均成功,研究组子宫内膜组织IGF-1表达术后明显低于术前,对照组术前及术后子宫内膜组织IGF-1表达变化无差异,二组相比,术后IGF-1表达差异有显著性。随访2年对照组224例患者中39例发生盆腔炎,复发率为10.89%,而研究组184例发生盆腔炎12例,差异有显著性;研究组子宫内膜厚度术后明显小于术前,差异有显著性,对照组子宫内膜厚度术后与术前变化无差异性。结论:左炔诺孕酮宫内释放系统对子宫内膜的IGF-1表达存在抑制作用,可能是其抑制子宫内膜增生并减少盆腔炎发生的机制之一。Objective：To study the effect of levonorgestrel intrauterine system on insulin-like growth factor-l（IGF-1）and the result of levonorgestrel intrauterine system prevention pelvic inflammatory disease. Methods：The 450 cases of hysteroscopic resection for endometrial polyps divided to study group（198 cases）who were placed levonorgestrel intrauterine system in uterus after hysteroscopic electroresection,and control group（252 cases）who were not placted at random. The IGF-1 expression of endometrial biopsy specimens during intraoperative and rechected after 6 months were check out by immunohis to chemistry. Patients were followed up for 2 years to analyse the effluence of pelvic inflammatory disease. Results：All patients had successful surgery. intraoperative specimens compared with afteroperation specimens of the IGF- 1 expression,there was a significant differences in study group but control group. Followed up for 2 years,14 cases has pelvic inflammatory disease in study group,39 cases has pelvic inflammatory disease in control group,there was a significant differences. The thickness of endometrium after operation is lower than before operation in study group but control group.Conclusions：It may be the main mechanism of prevention pelvic inflammatory disease and inhibition endometrium that levonorgestrel intrauterine system can prevent endometrial IGF-1 expression.

关 键 词：左炔诺孕酮宫内系统 胰岛素样生长因子 盆腔炎 

分 类 号：R6[医药卫生—外科学]