母体环境因素暴露与胎儿先天性心脏病病因关系探讨  

The relationship between maternal environmental factors and fetus congenital heart disease

作　　者：刘艳[1] 黄鹏[2] 孙晓如[1] 林宁[1] 喻荣彬[2] 石慧[1] 王丽娟[1] 

机构地区：[1]江苏省计划生育科学技术研究所,南京210036 [2]南京医科大学公共卫生学院,南京210029

出　　处：《中国工程科学》2015年第6期41-44,共4页Strategic Study of CAE

基　　金：江苏省科技厅自然科学基金(BK2011862)

摘　　要：探讨先天性心脏病与患儿母亲孕前及孕期环境因素暴露的关系。对先天性心脏病患儿的母亲面对面结构式访谈,填写调查问卷,共回收有效问卷373份,其中病例组157例,对照组216例。并分析孕前及孕期环境危险因素对胎儿先天性心脏病的影响。有先天性心脏病家族史、患儿母亲有流产史、不良妊娠史、孕期农药接触史、孕早期患病、孕早期用药、孕期胎儿异常与生育先天性心脏病患儿关系显著(P<0.05)。改善母亲健康状况,控制或减少工作生活环境中危险因素暴露,加强孕期检查,对于降低胎儿先天性心脏病发生风险尤为重要。To study the relationship between maternal risk factors and fetus congenital heart disease in Jiangsu province for exploration of effective prevention strategy. By 1∶1.4 case-control study,373 valid questionnaires were collected from July 2012 to December 2013 and the environmental risk factors of congenital heart disease were analyzed. It showed that the risks such as congenital heart disease family history,history of miscarriage,adverse pregnancy history,history of pesticide exposure during pregnancy,early pregnancy sickness,early pregnancy medication,pregnancy fetal abnormalities,were the most important determinants associated with CHD of children（P〈0.05）. It is particularly important of maternal health,reducing exposure to risk factors and periodic prenatal for reducing the risk of congenital heart disease.

关 键 词：胎儿 先天性心脏病 环境因素 

分 类 号：R725.4[医药卫生—儿科]