慢性阻塞性肺疾病患者免疫球蛋白的表达及与肺功能的关系  

Relationship between the expression of immune globulin and lung function in patients with chronic obstructive pulmonary disease

作　　者：陈昌枝[1,2] 邵有和[1,2] 覃家盟[1,2] 吴文彬[1,2] 

机构地区：[1]广西医科大学第八附属医院 [2]广西贵港市人民医院呼吸内科,广西贵港537100

出　　处：《临床肺科杂志》2015年第8期1404-1406,共3页Journal of Clinical Pulmonary Medicine

基　　金：广西贵港市科学研究与技术开发项目基金课题(No11145022)

摘　　要：目的探讨慢性阻塞性肺疾病(简称慢阻肺)患者免疫球蛋白的表达及与肺功能的关系。方法选取2011年6月至2013年6月在我院门诊随诊的稳定期慢阻肺患者62例作为慢阻肺稳定期组、呼吸内科住院的重症慢阻肺患者58例为慢阻肺急性加重期组(AECOPD)及本院体检中心行健康体检者50例为健康对照组。全部入选者均行肺功能检查并测定免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、C反应蛋白(CRP)和白蛋白(ALB)。结果 3组间IgA、IgG、CRP、ALB检测结果差异有统计学意义(P<0.05),慢阻肺急性加重期组和慢阻肺稳定期组中的IgA、IgG、ALB低于健康对照组、CRP高于健康对照组(P<0.05);慢阻肺急性加重期组中的ALB低于慢阻肺稳定期组、CRP高于慢阻肺稳定期组(P<0.05)。慢阻肺组患者的FEV1和FVC与IgG、IgA和ALB呈显著正相关(P<0.05),与CRP呈显著负相关(P<0.05)。结论慢阻肺患者存在体液免疫功能障碍,且随着病情的加重和肺功能的降低其免疫功能呈进行性减退。Objective To investigate the relationship between the expression of immune globulin and lung function in patients with chronic obstructive pulmonary disease. Methods The study selected 62 stable COPD pa-tients as the stable COPD group, 58 AECOPD patients as the AECOPD group and another 50 healthy subjects as the control group. Their lung function, IgM, IgG, IgA, CRP and ALB were detected. Results There were significant differences in IgA, IgG, CRP and ALB among the three groups （P 〈 0. 05）. The levels of IgA, IgG and ALB were lower and the level of CRP was higher in the AECOPD group and the stable COPD group than in the healthy control group （P 〈 0. 05）. The value of ALB was less and CRP was higher in the AECOPD group than in the stable COPD group （P 〈 0. 05）. The level of FEV1 and FVC was positively correlated with the value of IgG, IgA and ALB, and negatively correlated with CRP （P 〈 0. 05）. Conclusion Humoral immune dysfunction exists in COPD patients, and it worsens as their lung function decreases.

关 键 词：慢性阻塞性肺疾病 免疫球蛋白 C反应蛋白 白蛋白 

分 类 号：R563.9[医药卫生—呼吸系统]