新型含二茂铁基Mannich碱的合成与表征  

Synthesis and characterization of novel Mannich bases containing ferrocenyl

作　　者：刘玉婷[1] 宋思梦 尹大伟[1] 杨晓刚 

机构地区：[1]陕西科技大学化学与化工学院教育部轻化工助剂化学与技术重点实验室,陕西西安710021 [2]陕西生益科技有限公司,陕西咸阳712000

出　　处：《陕西科技大学学报（自然科学版）》2015年第4期70-74,共5页Journal of Shaanxi University of Science & Technology

基　　金：国家973科技计划前期专项项目(2014CB260411);国家自然科学基金项目(21176148);陕西省教育厅重点实验室科研计划项目(13JS017)

摘　　要：以乙酰基二茂铁、甲醛和取代苯胺为原料,盐酸为催化剂,在无水乙醇溶液中通过Mannich反应合成了两种新型含二茂铁基Mannich碱,其结构经IR、1 H MNR、13C NMR和元素分析得以确证.同时探索了以液体胺为原料合成含二茂铁基Mannich碱的新方法.并通过单因素法分析了反应温度、溶剂、反应体系pH值及原料摩尔比对产率的影响,确定了反应的最佳条件：无水乙醇作溶剂,乙酰基二茂铁、甲醛和取代苯胺的摩尔比为1.0∶3.0∶3.0,反应温度为80℃,反应体系的pH值为4~6.Two novel Mannich bases containing ferrocenyl were synthesized through Mannich reaction,with acetyl ferrocene,formaldehyde and substituted aniline as raw materials,hydrochloric acid as catalyst,anhydrous ethanol as solvent.Structures of new compounds were confirmed by IR,1 H NMR,13 C NMR and elemental analysis.While a new method was explored for the synthesis of Mannich base containing ferrocenyl from liquid amine.The optimum reaction conditions were determined by analyzing the effects of reaction temperature,solvent,pH and the ratio of the starting materials：That is anhydrous ethanol as solvent,the molar ratio of acetyl ferrocene,formaldehyde and substituted aniline is 1.0∶3.0∶3.0,the reaction temperature is 80 ℃,pH of the reaction system is 4~6.

关 键 词：乙酰基二茂铁 MANNICH反应 MANNICH碱 

分 类 号：O625.6[理学—有机化学]