丹红注射液对不稳定型心绞痛患者经皮冠状动脉介入治疗围手术期的疗效  

Perioperative effect of Danhong Injection in patients with unstable angina pectoris during percutaneous coronary intervention

作　　者：周维伟[1] 周迎[2] 张华巍[2] 

机构地区：[1]北京市顺义区医院药剂科,顺义101300 [2]解放军总医院心内科

出　　处：《中国循证心血管医学杂志》2015年第3期336-338,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的：评估丹红注射液对不稳定型心绞痛患者经皮冠状动脉介入治疗（PCI）围术期的疗效。方法选择2012年4月至2014年4月在顺义区医院住院并拟行PCI治疗的不稳定型心绞痛患者100例，其中男性70例，女性30例，年龄42~77岁，平均（58.0±9.2）岁。入院后随机分为对照组和治疗组，每组各50例。两组患者均接受常规药物治疗和PCI术，治疗组于PCI术前1~3 d加用丹红注射液治疗，围手术期共应用7 d。观察所有患者的临床疗效。所有患者均于PCI术前、术后24 h抽取静脉血，检测高敏C反应蛋白（hs-CRP）、白介素-6（IL-6）及心肌肌钙蛋白（cTnT）变化情况。结果治疗组显效27例（54%），有效14例（28%），总有效率为82%；对照组临床显效21例（42%），有效11例（22%），总有效率为64%。治疗组较对照组总有效率升高（82% vs.64%），差异有统计学意义（P＜0.05）。对照组术后较术前IL-6降低，cTnT升高，治疗组术后较术前hs-CRP和IL-6均降低，差异有统计学意义（P均＜0.05）。与对照组术后比较，治疗组hs-CRP[（0.40±0.70）mg/dl vs.（0.20±0.21）mg/dl]、IL-6[（2.52±2.49）pg/ml vs.（2.37±1.68）pg/ml]、cTnT[（0.12±0.0）ng/ml vs.（0.09±0.05）ng/ml]水平均降低，差异有统计学意义（P均＜0.05）。结论丹红注射液可改善不稳定型心绞痛患者临床疗效，抑制PCI围术期炎症反应，具有保护缺血心肌的作用。Objective To review the perioperative effect of Danhong Injection in patients with unstable angina pectoris （UAP） during percutaneous coronary intervention （PCI）. Methods UAP patients （n=100, male 70, female 30, aged from 42 to 77 and average age=58.0±9.2） were chosen from Apr. 2012 to Apr. 2014, and then divide randomly into control group and treatment group （each n=50）. All groups were given routine drugs and PCI, and treatment group was given additionally Danhong Injection 1 to 3 d before PCI and totally for 7 d during perioperative period. The clinical efficacy was observed in all patients. The vein blood samples were collected 24 h before PCI and 24 h after PCI for detecting the changes of high-sensitivity C-reactive protein （hs-CRP） interleukin-6 （IL-6） and cardiac troponin T （cTnT）. Results There were 27 cases （54%） with significant efficacy and 14 （28%） with efficacy, and the total effective rate was 82%in treatment group, and 21 cases （42%） with significant efficacy and 11 （22%） with efficacy, and the total effective rate was 64%in control group （P〈0.05）. In control group, IL-6 decreased and cTnT increased after PCI, and hs-CRP and IL-6 decreased （all P〈0.05）. After PCI, hs-CRP [（0.40 ±0.70） mg/dl vs. （0.20±0.21） mg/dl], IL-6 [（2.52±2.49） pg/ml vs. （2.37±1.68） pg/ml] and cTnT [（0.12±0.0） ng/ml vs. （0.09±0.05） ng/ml] all decreased in treatment group compared with control group （all P〈0.05）. Conclusion Danhong Injection can improve the clinical efficacy, inhibit perioperative inflammatory reactions and protect ischemic myocardium in patients with UAP.

关 键 词：丹红注射液 不稳定性心绞痛 PCI围术期 心肌保护 

分 类 号：R541.4[医药卫生—心血管疾病]