64排螺旋CT检测冠状动脉病变与髓过氧化物酶的相关性研究  

Correlation between 64-slice spiral computed tomography and myeloperoxidas in detection of coronary artery lesions

作　　者：马春梅[1] 吴建榕 叶道斌[1] 邓笑伟[1] 魏巍[1] 郭月玲[3] 

机构地区：[1]武警总医院健康医学中心,北京100143 [2]协和洛克生物技术有限责任公司 [3]北京军区总医院医工科

出　　处：《中国循证心血管医学杂志》2015年第3期339-341,共3页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探索64排螺旋CT检测冠状动脉(冠脉)病变与血浆髓过氧化物酶(MPO)水平的相关性。方法选择以胸痛为主要症状的患者254例,根据冠脉CT造影结果,分为正常对照(NC)组89例、稳定型心绞痛(SAP)组98例、急性冠脉综合征(ACS)组67例。所有患者均测定血糖、血脂、血压等指标。采用酶联免疫吸附法测定所有入选者血浆MPO浓度,用Gensini积分评价冠脉病变严重程度,比较组间血浆MPO浓度水平差异及血浆MPO浓度与Gensini积分的相关性。结果 ACS组血浆MPO平均浓度高于SAP组,SAP组血浆MPO平均浓度高于正常对照组,差异均有显著统计学意义(P<0.01)。在冠心病患者中,血浆MPO水平随着Gensini积分增加而升高(P<0.01),MPO浓度与Gensini积分呈显著正相关(r=0.51,P<0.01)。结论 64排螺旋CT冠脉检查进行Gensini积分与血浆MPO水平密切相关,两者联合评估冠脉病变严重程度有一定临床意义。Objective To investigate the correlation between 64-slice spiral computed tomography （64-slice CT） and concentration of myeloperoxidas （MPO） in detection of coronary artery lesions. Methods The patients with chest pain as main symptom were chosen （n=254）, and divided, according to the outcomes of coronary CT angiography, into normal group （n=89）, stable angina pectoris group （SAP group, n=98） and acute coronary syndrome group （ACS group, n=67）. The indexes of plasma glucose, blood fat and blood pressure were detected. The concentration of plasma MPO was detected by using enzyme-linked immunosorbent assay （ELISA） and severity of coronary artery lesions was reviewed by using Gensini integrals. The difference in MPO concentration, and correlation between MPO and Gensini integrals were analyzed. Results The mean concentration of plasma MPO was higher in ACS group than that in SAP group, and was higher in SAP group than that in normal group （P〈0.01）. In CHD patients, the concentration of plasma MPO increased as Gensini integrals ascended （P〈0.01）, and MPO was positively correlated to Gensini integrals （r=0.51, P〈0.01）. Conclusion Gensini integrals and MPO is closely related to each other during 64-slice CT, which have some clinical value in reviewing severity of coronary artery lesions.

关 键 词：髓过氧化物酶(MPO) 冠状动脉硬化 冠状动脉CT造影 

分 类 号：R816.2[医药卫生—放射医学]