肉豆蔻挥发油对缺血豚鼠心室肌动作电位及L型钙离子通道的影响  

Effects of the Essential Oil From Myristica Fragrans Houtt Seeds on Action Potential and L-type Calcium Channel in Ischemic Cardiomyocytes

作　　者：宣丽颖[1] 刘月英[1] 韩浩[1] 

机构地区：[1]内蒙古民族大学医学院,通辽028000

出　　处：《中国卫生标准管理》2015年第17期127-128,共2页China Health Standard Management

基　　金：内蒙古民族大学科学研究基金资助项目(项目编号:NMD1330)

摘　　要：目的研究肉豆蔻挥发油对缺血豚鼠心室肌动作电位及L型钙离子通道的影响。方法通过全细胞电流钳技术记录豚鼠单细胞动作电位,通过全细胞电压钳技术记录豚鼠心室肌L型钙通道电流。结果肉豆蔻挥发油可使豚鼠心室肌细胞动作电位时缩短,豚鼠心室肌L型钙离子电流幅值减小,具有剂量依赖性,有统计学意义(P<0.05,P<0.01)。结论肉豆蔻挥发油对缺血心肌起保护作用。Objective To investigate the effects of the essential oil from myristica fragrans houtt seeds on action potential and L-type calcium channel in ischemic cardiomyocytes.MethodsThe AP of ventricular myocytes was recorded by current-clamp mode and the current of L-type caleium channel was recorded by voltage-clamp mode using whole clamp technique.Results Action potential duration and the peak current of L-type caleium channel were decreased in the essential oil from myristica fragrans houtt seeds（P〈 0.05,P〈 0.01）.Conclusion The essential oil from myristica fragrans houtt seeds can protect ischemic cardiomyocytes.

关 键 词：肉豆蔻挥发油 全细胞膜片钳技术 动作电位 L型钙离子通道 

分 类 号：R28[医药卫生—中药学]