NT-proBNP和cTnI联合检测在儿童毛细支气管炎心肌损伤诊断中的应用  

Application of joint detection of NT-pro BNP and cTnI in diagnosis of bronchiolitis combined with myocardial injury in children

作　　者：汪玉堂[1] 张月霞[2] 韦祁山[2] 

机构地区：[1]西北民族大学医学院,甘肃兰州730030 [2]兰州市妇幼保健院儿科

出　　处：《中国妇幼保健》2015年第20期3502-3503,共2页Maternal and Child Health Care of China

基　　金：国家民委科研项目〔14XBZ023〕;兰州市科技计划项目〔2012-1-15〕

摘　　要：目的 探讨联合检测血清氨基末端脑利钠肽前体（NT-pro BNP）和血清肌钙蛋白（c Tn I）水平在毛细支气管炎心肌损伤诊断中的应用价值。方法 选取2013年8月-2014年10月在该院因毛细支气管炎住院的患儿46例为毛细支气管炎组,于急性期及恢复期检测血清NT-pro BNP和c Tn I水平;另选取正常儿童32例为对照组,检测其NT-pro BNP和c Tn I水平,并对两组检测结果进行比较分析。结果 毛细支气管炎组急性期血清NT-pro BNP和c Tn I水平最高,恢复期NT-pro BNP和c Tn I水平均下降,但仍高于对照组（P均〈0.05）,急性期血清NT-pro BNP与c Tn I呈直线正相关（r=0.725,P〈0.05）。结论 对毛细支气管炎患儿进行NT-pro BNP和c Tn I联合检测,并动态观察其变化,能够尽早发现心肌损伤,指导临床治疗。Objective：To explore the application value of joint detection of serum N-terminal pro-brain natriuretic peptide（NTpro BNP） and cardiac troponin I（cTnI） in diagnosis of bronchiolitis combined with myocardial injury in children.Methods：Forty-six hospitalized children with bronchiolitis were selected from the hospital from August 2013 to October 2014 as bronchiolitis group,serum NT-pro BNP and cTnI levels at acute phase and recovery phase were detected; thirty-two healthy children were selected as control group,the levels of serum NT-proBNP and cTnI were detected; the results in the two groups were compared and analyzed.Results：The levels of serum NT-pro BNP and cTnI at acute phase in bronchiolitis group were the highest,which decreased as recovery phase,but the levels of serum NTpro BNP and cTnI were still statistically significantly higher than those in control group（P〈0.05）; at acute phase,there was a positively linear correlation between serum NT-pro BNP and cTnI（r = 0.725,P〈0.05）.Conclusion：Conducting joint detection of NT-pro BNP and cTnI and observing the dynamic changes can find myocardial injury among children with bronchiolitis and direct clinical treatment.

关 键 词：氨基末端脑利钠肽前体 血清肌钙蛋白 毛细支气管炎 心肌损伤 

分 类 号：R562.21[医药卫生—呼吸系统]