萘磺酸钠修饰的石墨烯基Fe_3O_4复合材料的制备与载药性能评价  

Preparation and evaluation of drug delivery properties of naphthalene sulfonate modified grapheme oxide-based Fe_3O_4 composites

作　　者：申玉坤[1,2] 龚连生[2] 申玉璞[1,2] 潘一峰[2] 

机构地区：[1]长治医学院,山西长治046000 [2]中南大学湘雅医学院,湖南长沙410008

出　　处：《中国医院药学杂志》2015年第13期1168-1172,共5页Chinese Journal of Hospital Pharmacy

基　　金：国家863计划资助项目(编号:2007AA021809)

摘　　要：目的:制备采用1-萘磺酸钠修饰的石墨烯基Fe3O4复合材料,并对其性能进行评价。方法:用1-萘磺酸钠进行修饰制备石墨烯基Fe3O4复合材料Fe3O4/GO-NA,同时进行磁性测定,然后包封盐酸多柔比星(DOX),得到Fe3O4/GO-NA/DOX,用高效液相色谱法测定DOX的含量,对其高效装载、缓释性、稳定性和细胞毒性进行分析。结果:Fe3O4/GO-NA具有超顺磁性,饱和磁化强度为16.5 emu·g-1,Fe3O4/GO-NA/DOX对DOX的载药率为(68.59±1.02)%(n=3),缓释性及稳定性良好,并且基本无生物毒性。结论:Fe3O4/GO-NA/DOX制备工艺可行,性能良好,具有广阔的应用前景。OBJECTIVE To prepared naphthalene sulfonate modified grapheme oxide-based Fe3O4 composite materials,and evaluate its quality performance.METHODS Sodium naphthalene sulfonate grapheme oxide Fe3 O4 composite materials（Fe3O4/GO-NA）were prepared,and its magnetic performance was measured,then DOX was included to obtain Fe3O4/GONA/DOX.The concentration of DOX was determined by high efficiency liquid chromatography.The high-efficiency loading,sustained-release performance,stability and cellular toxicity were analyzed.RESULTS Fe3O4/GO-NA could be considered as super paramagnetism,and its saturation magnetization was 16.5 emu·g-1.The loading rate of Fe3O4/GO-NA/DOX for DOX was（68.59±1.02）%（n=3）.Fe3O4/GO-NA/DOX had a good sustained-release performance and stability,and showed no biological toxicity.CONCLUSION The preparation technique of Fe3O4/GO-NA/DOX is feasible,which has good performance,and broad application prospects.

关 键 词：石墨烯 FE3O4 萘磺酸钠 复合材料 

分 类 号：R969[医药卫生—药理学]