中药调节内质网应激的研究进展  

Advances of the traditional Chinese medicines modulating endoplasmic reticulum stress

作　　者：周华娜[1] 姜楠[1] 韩雨薇[1] 寇俊萍[1] 

机构地区：[1]江苏省中药评价与转化重点实验室,中国药科大学中药复方研究室,南京211198

出　　处：《中国药科大学学报》2015年第4期385-392,共8页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81274004);江苏省高校优势学科建设工程资助项目~~

摘　　要：内质网是真核细胞中蛋白质合成、折叠与分泌的重要细胞器,内质网内稳态失衡时,即发生内质网应激(endoplasmic reticulum stress,ERS)。调节细胞内质网应激是防治多种疾病的重要途径和策略之一。本文综述了近3年中药调节肿瘤、心血管疾病、神经系统疾病、糖尿病等相关细胞的内质网应激的研究进展,为阐释中药防治相关重大疾病的作用特点和可能机制提供线索和参考。The endoplasmic reticulum is an important organelle for eukaryotic cell protein synthesis, folding and secretion. Perturbation of endoplasmic reticulum homeostasis causes endoplasmic reticulum stress. It has been considered as one of important ways and new strategies to regulate endoplasmic reticulum stress in the treatment of multiple diseases. This paper mainly reviews the advances in the research on traditional Chinese medicines for modulating endoplasmic reticulum stress related to cancer, cardiovascular diseases, neurological diseases, diabetes and other complex diseases in recent years, aiming to provide some clues and references for exploring the charac- teristics and possible mechanism of traditional Chinese medicines treating related diseases.

关 键 词：内质网应激 中药 肿瘤 心血管疾病 神经系统疾病 糖尿病 

分 类 号：R285[医药卫生—中药学]