丁苯酞治疗急性缺血性脑卒中患者的临床效果及对其hs-CRP的影响  

Clinical effect of butyl phthalide therapy on patients with acute ischemic stroke and its influence on hs-CRP

作　　者：马荣芳[1] 江玉玲[1] 

机构地区：[1]信阳职业技术学院附属医院神经内科,河南信阳464000

出　　处：《中国实用医刊》2015年第14期58-59,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨丁苯酞治疗急性缺血性脑卒中患者的临床效果，观察该治疗方法对血清超敏C．反应蛋白（hs-CRP）的影响。方法将120例急性缺血性脑卒中患者纳入本研究，随机分为研究组和对照组，对照组选择常规疗法，研究组在常规治疗的同时联合使用丁苯酞胶囊，治疗2周后观察临床疗效及血清hs．CRP变化状况。结果研究组治疗总有效率（85．00％）显著高于对照组（65．00％），差异有统计学意义（X^2=12．993，P=0．011〈0．05）；两组患者在治疗2周后NIHss评分均明显低于治疗前，研究组NIHSS评分明显低于对照组，差异均有统计学意义（P〈0．05）；两组hs-CRP均较治疗前水平显著降低；研究纽hs-CRP水平与对照组降低程度更低，且差异有统计学意义（P〈0．05）。结论丁苯酞治疗急性缺血性脑卒中患者的临床疗效较为显著，且可有效降低血清中hs-CRP浓度，缓解患者机体内炎症反应程度，有效控制脑卒中病情，有助于预后，时临床治疗具有重要意义。Objective To investigate the clinical effect of butylphthalide on acute ischemic stroke, and observe the effect of the treatment on serum hs-CRP. Methods One hundred and twenty patients with acute ischemic stroke were en- rolled in this study, and were randomly divided into study group and control group. The control group reloived conventional therapy and the study group used butylphthalide capsules on the bais of conventional treatment at the same time. After 2 weeks of treatment,the clinical observation efficacy and change of serum high sensitivity C reactive protein （haoGRp） were observed. Results The total effective rate （85%） in study group was significantly higher than that of the control group （65%）, and there was significant difference between the two groups （X2 = 12. 993, P =0. 011 〈0. 05）. Two weeks after the treatment, NIHSS score were significantly lower than that before treatment in both groups, and the NIHSS score and in study group was significantly lower than that of the control group （P 〈 0. 05 ）, The hs-CRP levels reduced significantly compared with that before treatment in both groups, and the differences in study group was more significantly compared with the control group （P 〈 0. 05）. Conclusions The more significant clinical effect of butyl phthalide therapy in patients with acute ischemic stroke can effectively reduce the serum levels of hs-CRP in patients with body, relieve the degree of inflammatory reaction, effec- tively control the progress of stroke, contribute to the prognosis and has important significance for clinical treatment.

关 键 词：丁苯酞 急性缺血性脑卒中 超敏C-反应蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]