枸杞子提取物对小鼠肠道菌群失衡的调整作用  

Regulating Effects of Fructus Lycii Extracts on Dysbiosis of Intestinal Flora of Mice

作　　者：刘云婷[1] 徐巍[1] 辛毅[1] 李新莉[1] 

机构地区：[1]大连医科大学生物技术系,大连116044

出　　处：《天然产物研究与开发》2015年第7期1270-1272,1295,共4页Natural Product Research and Development

摘　　要：本研究旨在探讨枸杞子不同浓度提取物对小鼠肠道菌群失衡的调整作用,为枸杞子的进一步开发利用提供理论依据。使用抗生素建立肠道菌群失衡模型,将小鼠随机分为正常对照组、枸杞子提取物高浓度组、低浓度组、模型组和自然恢复组,以双歧杆菌、乳酸杆菌、肠杆菌、肠球菌等肠道正常菌群为对象,利用传统菌落计数法研究各组肠道菌群失衡及恢复调整情况。枸杞子提取物对乳酸杆菌和双歧杆菌的生长具有恢复作用,且低浓度提取物的增殖作用优于高浓度,而对肠球菌和肠杆菌的作用并不明显。枸杞子提取物对小鼠肠道菌群失衡有一定的调整作用,能够纠正抗生素相关性菌群失调。To investigate the regulating effects of different concentrations of Fructus Lycii extracts on antibiotics-induced dysbiosis of intestinal flora in mice,to supply theoretical basis for further development and utilization of Fructus Lycii. The mice model of intestinal dysbiosis was established by treating with antibiotics.Mice were randomly divided into five groups：normal control group,high concentration extract group,low concentration extract group,model group and spontaneous recovery group.Taking Bifidobacterium, Lactobacillus, Enterobacteria and Enterococcus as investigating targets,traditional culturing method was used to examine the predominant microbial population changes of intestinal flora.Low concentration extracts of Fructus Lycii showed promoting effects on Bifidobacterium and Lactobacillus, which was better than that of high concentration group.However,the promoting effects on Enterobacteria and Enterococcus were unobvious.Based on these results,it was concluded that Fructus Lycii extracts can regulate intestinal flora and correct intestinal microbe dysbiosis caused by antibiotics.

关 键 词：枸杞子 肠道菌群 调整作用 

分 类 号：R285.5[医药卫生—中药学]