我院2013-2014年万古霉素临床应用分析  

Analysis of Clinical Application of Vancomycin in Our Hospital from 2013 to 2014

作　　者：谢慧[1] 姜顺军[1] 陈文瑛[1] 肖翔林[1] 喻鹏久[1] 

机构地区：[1]广州医科大学附属第一医院药学部,广州510120

出　　处：《中国药房》2015年第20期2756-2759,共4页China Pharmacy

摘　　要：目的:为进一步制定万古霉素合理使用规范提供依据。方法:回顾性分析我院2013年6月-2014年12月经静脉使用万古霉素的正常出院患者的相关信息。结果:178例使用万古霉素的患者,平均年龄59.6岁,男性占73.60%,以肺部感染为主(74.72%)。用药前辅助检查充分,66.29%属经验性治疗用药,病原学送检率达85.39%。71.91%的患者行治疗药物监测,但首次监测血药浓度仅47.66%处于目标范围。结论:万古霉素在我院使用较为合理,但需关注经验性用药疗程、治疗药物监测的合理性以及个体化初始剂量等问题。OBJECTIVE： To provide reference for further formulation of the rational use of vancomycin. METHODS： Retro- spective analysis was conducted on the related information of discharged patients who intravenously used vancomycin from Jun. 2013 to Dec. 2014. RESULTS： 178 patients were enrolled, with average age of 59.6 and 73.60% male, who were mainly with lung infectious （74.72 % ）. Support examinations were sufficient before using of vancomycin. 66.29% patients were empirically giv- en vancomycin with pathogenic detection rate of 85.39%. 71.91% patients were conducted therapeutic drug monitoring with only 47.54% of first blood samples achieved the target range. CONCLUSIONS： Vancomycin application is generally rational in our hos- pital. However, issues like duration of empirical therapy, rational therapeutic monitoring, and individualized start dosing still need to be noticed.

关 键 词：万古霉素 处方分析 治疗药物监测 合理用药 

分 类 号：R978.1[医药卫生—药品] R969.3[医药卫生—药学]