气道分泌物廓清技术集束化管理在氧气驱动雾化吸入疗法中的应用  

Application of Airway Secretions Expurgation Cluster Management in Oxygen-driven Aerosol Inhalation Therapy

作　　者：刘羽[1] 王之赫 何晓玲[1] 王莹[1] 穆秀 陆思静[1] 

机构地区：[1]辽宁医学院附属第一医院,辽宁锦州121000

出　　处：《中国药房》2015年第20期2811-2813,共3页China Pharmacy

摘　　要：目的:评价在氧气驱动雾化吸入治疗时进行气道分泌物廓清技术集束化管理的有效性及安全性。方法:选取慢性阻塞性肺病急性加重期患者280例,按随机数字表法分为A、B、C、D组,各70例,A、B组应用复方异丙托溴铵2 ml加生理盐水5 ml,10min/次,每日2次,6 L/min氧气驱动雾化吸入治疗7 d;C、D组应用盐酸氨溴索注射液15 mg加生理盐水5 ml,10 min/次,每日2次,6 L/min氧气驱动雾化吸入治疗7天。A组和C组为治疗组,B组和D组为对照组。两治疗组患者在吸入相应药物治疗的同时进行气道分泌物廓清技术集束化管理,两对照组患者在吸入相应药物治疗的同时进行单一的有效咳嗽指导。结果:治疗组患者咳痰量增多、动脉血氧分压(Pa O2)提高、动脉血二氧化碳分压(Pa CO2)下降、住院时间缩短,与对照组比较差异有统计学意义(P<0.05)。结论:在氧气驱动雾化吸入疗法中进行气道分泌物廓清技术集束化管理是慢性阻塞性肺疾病治疗中一种简便、安全、有效的方法。OBJECTIVE： To evaluate the efficacy and safety of the application of airway secretions expurgation cluster manage- ment in oxygen-driven aerosol inhalation. METHODS： 280 patients with chronic obstructive pulmonary disease in the Respiratory Second Division of our hospital from Mar. 2012 to Dec. 2013 were randomly divided into group A, B, C and D, with 70 cases in each group.Group A and B were treated with compound isopropyl bromide 2 rnl＋nomal saline 5 ml, 10 min/time, twice a day, and 6 L/min oxygen-driven aerosol inhalation for 7 days;group C and Dreceived Ambroxol hydrochloride injection 15 ml＋normal saline 5 ml, 10 min/time, twice a day, and 6 L/min oxygen-driven aerosol inhalatiom for 7 days. group A and C were treatment groups, group B and D were control groups. Two treatment groups inhaled compound medications while the application of airway secretions expurgation cluster management. Two control groups inhaled compound medications with single effective cough guidance. RE- SULTS： Compared with control groups, the patients in treatment groups eliminated more phlegm, had lower （PaCO2）and higher （PaO2）, also had a shorter hospitalization period, with significant difference （P〈0.05）. CONCLUSIONS： Airway secretions expur- gation cluster management technology is a simple, safe and effective method, especially in patients with chronic obstructive pulmo- nary disease in oxygen-driven inhalation therapy.

关 键 词：气道分泌物廓清技术集束化管理 氧气驱动雾化吸入疗法 慢性阻塞性肺部疾病急性加重 

分 类 号：R974[医药卫生—药品] R969.4[医药卫生—药学]