替罗非班不同输注时间对心肌灌注的影响  

Effects of tirofiban maintenance duration on myocardial perfusion

作　　者：邓四军[1] 孙立平[1] 李玉伟[1] 王助衡[1] 

机构地区：[1]首都医科大学大兴医院,北京102600

出　　处：《岭南心血管病杂志》2015年第3期298-301,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的研究替罗非班不同的输注时间对心肌灌注缺损情况的影响。方法将84例接受经皮冠状动脉介入(percutaneous coronary intervention,PCI)治疗的急性前壁心肌梗死患者按随机数字表法随机分为2组,分别给予替罗非班输注24 h和48 h。术后5 d接受锝99标记的心肌灌注扫描,比较心肌灌注情况。结果接受替罗非班输注48 h组的心肌灌注指标优于24 h组,差异有统计学意义[心肌灌注评分:(11.97±7.34)分vs.(15.61±4.6)分,P<0.05]。结论延长替罗非班的输注时间至48 h是安全的,并可以改善ST段抬高型心肌梗死患者PCI治疗后心肌灌注。Objectives To investigate if myocardial perfusion can be changed by different infusion duration of tirofiban.Methods A total of 84 patients with acute anterior ST-elevation myocardial infarction（STEMI） receiving percutaneous coronary intervention（PCI） were randomly allocated to two groups. Each patient received a tirofiban infusion for 24 or48 hours depending on allocation, respectively. A resting 99 m Tc-sestamibi scan was performed on the 5th day after PCI procedure. The primary efficacy endpoint was a patient ＇s score on a 5-point scoring system for rating perfusion defect severity. Results Patients receiving tirofiban infusions for 48 hours had significant reductions in perfusion defect severity [（11.97 ±7.34） vs.（15.61 ±4.6）, P〈0.05 ]. Conclusions Tirofiban maintaining for 48 h is safe and can significantly reduce perfusion defect severity in patients with STEMI undergoing PCI.

关 键 词：心肌梗死 替罗非班 心肌灌注显像 血管成形术 经皮 经腔冠状动脉 

分 类 号：R542.22[医药卫生—心血管疾病]