荆芥挥发油的提取及包合工艺研究  

Study of Schizonepeta Volatile Oil Extraction Process and Inclusion Process from Herba Schizonepetae

作　　者：王晓莉[1] 孙四海[1] 李凌云[1] 邵洪锦[1] 贾曼[1] 周焕芹[1] 

机构地区：[1]聊城市人民医院,山东聊城252000

出　　处：《中国药物评价》2015年第3期155-158,共4页Chinese Journal of Drug Evaluation

摘　　要：目的:采用水蒸气蒸馏法提取荆芥挥发油,优选提取工艺及包合工艺。方法:以挥发油的提取量为考察指标,以加水量、浸泡时间、提取时间作为3个主要的考察因素,通过L9(34)正交试验法优化荆芥挥发油最佳提取工艺。以挥发油与β-环糊精的比例、溶剂用量、时间为考察因素,优选挥发油的包合工艺。结果:最佳提取工艺为饮片加水12倍量,浸泡3 h,提取8 h;最优包合工艺为挥发油与β-环糊精比例为1∶10,加入溶剂量为3倍量,胶体磨碾磨时间为15 min。结论:优选的提取工艺和包合工艺简便、快速、稳定、可行,可作为荆芥挥发油产业化生产工艺。Objective：To extract schizonepeta volatile oil from herba schizonepetae with steam distillation method,optimize the extraction process and inclusion process. Methods： The weight of schizonepeta volatile oil was taken as the observation index, water adding volume,soak time and extraction time were taken as 3 main factors. L9 （ 3^4 ） orthogonal test was adopted to optimize the best extraction process. The proportion of β-cyclodextrin and oil, the amount of extraction solvent and time as factors, to optimize the best inclusion process. Results： The best extraction process： 12 times of water adding volume, 3 h soaking,2 h extraction. The best inclusion process： the proportion of β-cyclodextrin and oil was 1： 10, the amount of solvent was 3 times, grinding time was 15 min. Conclusion：The optimum processes are simple, steady and attainable, can be used as industrial production process.

关 键 词：荆芥 挥发油 工艺研究 

分 类 号：R283.6[医药卫生—中药学]