三磷酸腺苷结合盒外排子对变异链球菌毒力因子影响的研究进展  

Effects of ATP-binding cassette exporters on virulence factors in Streptococcus mutans

作　　者：曾荟荟[1] 凌均棨[1] 

机构地区：[1]中山大学光华口腔医学院·附属口腔医院,广东省口腔医学重点实验室,广州510055

出　　处：《中华口腔医学研究杂志（电子版）》2015年第3期56-60,共5页Chinese Journal of Stomatological Research(Electronic Edition)

摘　　要：三磷酸腺苷结合盒(ABC)转运子是膜蛋白的一部分,透过细胞膜转运各种生物分子,参与多种生理功能。在变异链球菌中,ABC外排子与基因感受态、四(五)磷酸鸟苷[(p)pp Gpp]累积、细菌素分泌与免疫密切相关。本文就变异链球菌ABC外排子的结构、生理功能、作用机制和抑制剂作一综述。ABC transporters have been proved to be integral membrane proteins that actively transported a diverse range of substrates across cell membranes. ABC transporters had varied functions, and took part in gene competence, （p）ppGpp accumulation, bacteriocin secretion and immunity in Streptococcus mutans. The structures, functions, mechanisms and inhibitors of the known ABC exporters in Streptococcus mutans were summarized.

关 键 词：ATP结合匣式转运子 ABC外排子 变异链球菌 抑制剂 

分 类 号：R378[医药卫生—病原生物学]