日常铅暴露对行辅助生殖技术女性月经紊乱、自然流产、优质胚胎率的影响  

Influence of lead exposure on menstrual disorders,spontaneous abortion,high-quality embryo in women subjected to assisted reproductive technology

作　　者：张宁[1] 汤晓峰[2] 陈颖[2] 张妍[1,3] 吴斌[3] 王鹏[3] 袁瑶[3] 施惠娟[3] 张树成 周维谨[1,3] 

机构地区：[1]复旦大学公共卫生学院,上海200032 [2]上海集爱遗传与不育诊疗中心 [3]上海市计划生育科学研究所国家人口和计划生育委员会计划生育药具重点实验室 [4]国家卫生计生委科学技术研究所

出　　处：《中国计划生育学杂志》2015年第7期447-450,共4页Chinese Journal of Family Planning

基　　金：国家科技基础性工作专项(2013FY110500);国家重点基础研究发展计划(973计划;2010CB530400)

摘　　要：目的：研究日常生活中铅暴露对行辅助生殖技术女性的生殖危害,以初步探索血铅含量与月经紊乱、自然流产及优质妊娠率的关系。方法：选择在医院行辅助生殖技术,不育原因为女方因素的女性,使用石墨炉原子吸收分光光度计测定女性血中铅含量。结果：所有受试对象血铅测量均数为30.98（0~319.74）μg/L,含量超标者（血铅≥100μg/L）21人（4.49%）。本研究未发现日常铅污染同女性月经周期异常、自然流产及优质胚胎率的统计学关系。结论：本试验未发现铅污染与月经紊乱、自然流产、优质胚胎率相关性,铅污染是否会对女性生殖及其子代产生损害,还需大样本研究。Objective：To explore the influence of lead exposure on menstrual disorders,spontaneous abortion,highquality embryo in women in women subjected to assisted reproductive technology.Methods：Women who were subjected to assisted reproductive technology for female infertility were recruited.The blood lead concentration was measured by graphite oven atomic spectrophotometer.Results：The average lead concentration was 30.98（0-319.74）μg/L.The blood lead concentration exceeded the normal range in 21（4.49%）women.No statistical relationships between the blood lead concentration with the incidence of menstrual disorders and spontaneous abortion as well as the good quality embryo rate were found.Conclusion：This study suggests that high concentration of blood lead may have no relationship with the incidence of menstrual disorders and spontaneous abortion as well as the good quality embryo rate.Large scale study is need to verify whether the lead pollution could result in the damage on female reproduction function and their offspring.

关 键 词：铅 月经紊乱 自然流产 优质胚胎 辅助生殖 

分 类 号：R714.8[医药卫生—妇产科学]