米非司酮配伍米索前列醇终止16～24周妊娠的临床研究  

Efficacy and safety of mifepristone combined with misoprostol for termination of pregnancy between 16 and 24 weeks of gestation

作　　者：钱金凤[1] 王彩燕[1] 诸葛听[1] 黄紫蓉[1] 

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《中国计划生育学杂志》2015年第7期461-464,共4页Chinese Journal of Family Planning

摘　　要：目的：探讨米非司酮配伍米索前列醇终止16~24周妊娠的有效性和安全性。方法：研究对象随机分组,分别采用米非司酮配伍米索前列醇（药物组）或米非司酮配伍依沙吖啶羊膜腔内注射（手术组）引产,各53例,胎儿及胎盘排出后药物组不做常规清宫,手术组常规清宫。结果：药物组和手术组胎儿排出率分别为94.3%、98.1%,差异无统计学意义（P〉0.05）;首次用药至胎儿排出时间分别为（48.7±7.0）h和（38.5±9.4）h,宫缩至胎儿排出时间分别为（10.6±6.7）h和（14.2±9.0）h,差异均有统计学意义（P〈0.05）;药物组清宫率18.9%,以院内清宫为主。结论：米非司酮配伍米索前列醇终止16~24周妊娠安全、有效,避免了羊膜腔穿刺,是终止16~24周妊娠安全可靠的方案之一。Objective：To explore the efficacy and safety of mifepristone combined with misoprostol for termination of pregnancy between 16 and 24weeks of gestation.Methods：Women recruited were randomized to two groups：53 in medical abortion group and 53 in ethacridine group.Routine surgical evacuation was only performed in ethacridine group after the expulsion of placenta.Results：The incidence of fetus expulsion was 94.3%in the medical group and98.1%in the ethacridine group,showing no significant difference;The mean induction-to-abortion interval was（48.7±7.0）h and（38.5±9.4）h,showing significant difference in two groups;The uterine contraction-to-abortion time was（10.6±6.7）h and（14.2±9.0）h in two groups,showing significant difference;The incidence of surgical evacuation in medical group was 18.9% most of which was immediate evacuation.Conclusion：vaginal misoprostol combined with mifepristone without invasive procedures is effective and safe for termination of pregnancy between 16and24 weeks of gestation.

关 键 词：米非司酮 米索前列醇 人工流产 依沙吖啶 中期妊娠 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]