2型糖尿病胰岛β细胞分泌功能与胰岛素抵抗指数的变化及其临床意义  

Research on β cell function and insulin resistance in patients with type 2 diabetes mellitus

作　　者：孙剑[1] 杜群[1] 王国萍[1] 王国君[1] 

机构地区：[1]包头医学院第二附属医院内分泌科,014030

出　　处：《中国糖尿病杂志》2015年第7期592-594,共3页Chinese Journal of Diabetes

摘　　要：目的观察胰岛β细胞分泌功能与胰岛素抵抗指数(HOMA-IR)在T2DM中的变化。方法T2DM患者268例,行75g OGTT或100g馒头餐试验,以及C-P释放试验,比较组间各项相关指标的差异。结果与病程<5年组比较,病程>10年组胰岛β细胞功能(HOMA-β)下降(P<0.05)。病程>10年组随FPG增加,HOMA-β下降(P<0.01),HOMA-IR增加,但差异无统计学意义(P>0.05)。结论长期良好的控制血糖,可延缓胰岛β细胞功能的衰竭。病程对HOMA-β的损伤低于高血糖。Objective To evaluateβcell function,insulin resistance and their changes in patients with type 2diabetes mellitus（T2DM）. Methods A total of 268T2 DM patients were enrolled in this study.75 g OGTT or 100 g steamed bread meal test and C-peptide release test were measured in all the subjects. Results Theβcell function index（HOMA-β）decreased significantly during the progress of T2DM（P〈0.05）.In T2 DM duration〉10years group,the decrease of HOMA-βand the increase in HOMA-IR associated with the increase of FPG did not reach the significant difference（P〈0.05）.Together with the raising of FPG level,HOMA-βdecreased,and the HOMA-IR increased significantly（P〈0.01）. Conclusion Long-term,well-controlled blood glucose could delay the exhaustion ofβcell function.Injury toβcell function based on duration of diabetes is less severe than that of hyperglycemia.

关 键 词：胰岛Β细胞功能 胰岛素抵抗 糖尿病 2型 口服葡萄糖耐量试验 

分 类 号：R587.1[医药卫生—内分泌]