糖尿病视网膜病变患者血清可溶性CD40配体水平的变化及其临床意义  

The change and clinical significance of serum soluble CD40 ligand level in diabetic retinopathy

作　　者：吴乃君[1] 刘颖[1] 金秀平[1] 魏剑芬[1] 王颖[1] 陈冬[1] 盛佳曦[1] 

机构地区：[1]河北联合大学附属医院内分泌科,唐山063000

出　　处：《中国糖尿病杂志》2015年第7期631-633,共3页Chinese Journal of Diabetes

摘　　要：目的探讨不同分期DR患者血清可溶性CD40配体(SCD40L)水平的变化及其临床意义。方法将91例T2DM患者分为单纯T2DM组36例、非增殖型DR(NPDR)组30例和增殖型DR(PDR)组25例,另选体检健康者25名为健康对照(NC)组。采用ELISA检测各组血清SCD40L水平。结果T2DM组血清SCD40L水平较NC组高[(310.17±37.78)vs(200.34±14.21)pg/ml,P<0.05],NPDR、PDR组较T2DM组高[(384.89±37.78),(480.52±47.17)vs(310.17±37.03)pg/ml,P<0.05],且PDR组较NPDR组高[(480.52±47.17)vs(384.89±37.78)pg/ml,P<0.05]。Logistic回归分析结果显示,病程、SCD40L为DR的影响因素。结论 DR患者血清SCD40L水平升高,SCD40L在DR发生发展中起重要作用。Objective To investigate the change and clinical significance of serum soluble CD40ligand（SCD40L）level in different stages of DR. Methods 91T2 DM patient were divided into three groups：T2DM without DR（T2DM）group（n=36）,T2 DM with nonproliferative DR（NPDR）group（n=30）and T2 DM with proliferative DR（PDR）group（n=25）.Healthy subjects in routine examination were selected as normal control（NC）group（n=25）.Serum SCD40 Llevels were measured by ELISA in each group. Results Serum SCD40 Llevel was significantly higher in T2 DM group than in NC group[（310.17±37.78）vs（200.34±14.21）pg/ml,P〈0.05].Serum SCD40 Llevel was higher in NPDR and PDR groups than in T2 DM group [（384.89±37.78）vs（310.17±37.03）pg/ml,P〈0.05;（480.52±47.17）vs（310.17±37.03）pg/ml,P〈0.05].Serum SCD40 Llevel was higher in PDR group than in NPDR group[（480.52±47.17）vs（384.89±37.78）pg/ml,P〈0.05].Logistic multivariate regression analysis showed that,T2 DM duration and SCD40 L were associated factors for DR. Conclusion Serum SCD40 Llevel increased in DR patients.Serum SCD40 Lmay play an important role in the progress of DR.

关 键 词：糖尿病 2型 糖尿病视网膜病变 可溶性CD40配体 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]