射干麻黄汤对哮喘患者气道高反应性的影响  

Effect of Sheganmahuang Decoction on Airway Hyperresponsiveness of Patients with Asthma

作　　者：杨硕[1] 罗光伟[1] 万军[1] 夏倩[1] 陈菁[1] 袁文胜[1] 孙洁民[1] 聂红[1] 

机构地区：[1]武汉市第一医院呼吸科,湖北武汉430022

出　　处：《湖北中医药大学学报》2015年第3期21-23,共3页Journal of Hubei University of Chinese Medicine

基　　金：武汉市卫生局课题(武卫【2007】43号)

摘　　要：目的观察射干麻黄汤对寒哮患者气道高反应性的影响。方法 51例轻、中度寒哮患者随机分为两组。对照组给予沙丁胺醇气雾剂,治疗组在对照组的基础上加用射干麻黄汤中药配方颗粒冲服,两组均治疗12周,分别于治疗前和治疗后进行哮喘控制测试评分(ACT评分)、最大呼气峰流速(PEF)、肺通气功能及支气管激发或舒张试验检测,并进行疗效判定。结果治疗组疗效优于对照组(P<0.05),两组FEV1、FEV1%预计值、PEF均较治疗前显著改善(P<0.05),而治疗组气道高反应性(支气管激发或舒张实验阳性率)及PEF变异率均较对照组下降(P<0.05),ACT评分较对照组明显改善(P<0.05)。结论射干麻黄汤能改善哮喘患者的症状及气道高反应性。Objective To observe the effect of Sheganmahuang decoction on airway hyperresponsiveness of cold asthma patients .Meth-ods 51 cases of light or moderate cold asthma patients were randomly divided into two groups .Control group used salbutamol aerosol inhala -tion and the treatment group used Sheganmahuang decoction based on the control group .Both groups were treated for 12 weeks.Before and af-ter treatment, the asthma control test score（ACT score）, forced expiratory volume in one second （FEV1） and peak expiratory flow （PEF） were observed, and the therapeutic effect was evaluated .Results The curative effect of treatment group was superior to the control group （P＆lt;0.05）,FEV1, FEV1% predicted value, PEF in two groups improved significantly than before treatment （P〈0.05）, but the treatment group with bronchial hyperresponsiveness （bronchial provocation or relaxation of the positive rate ） and PEF mutation rate were significantly decreased than that of control group （P〈0.05）, ACT score were significantly improved than control group （P〈0.05）.Conclusion She-ganmahuang decoction can improve the symptoms and airway hyperresponsiveness in asthma patients .

关 键 词：支气管哮喘 射干麻黄汤 气道高反应性 

分 类 号：R259[医药卫生—中西医结合]