罐组逆流提取技术在双泽清脂颗粒技术改造升级中的应用研究  

Multi-stage Countercurrent Extraction Process in Application of Shuangzeqingzhi Granules

作　　者：饶双超 冯玲华 毛小红 

机构地区：[1]湖北省英山县人民医院,湖北黄冈438700

出　　处：《湖北中医药大学学报》2015年第3期40-42,共3页Journal of Hubei University of Chinese Medicine

基　　金：湖北省自然科学基金资助项目(2011CDB168)

摘　　要：目的确定双泽清脂颗粒罐组逆流提取的产业化生产工艺。方法采用单因素及正交试验的方法,以大黄酚的转移率和浸膏得率的加权得分为综合评价指标,考察每罐每次提取加水量、提取时间、提取溶剂温度及混合药材粉碎粒度对提取工艺的综合影响,确定最佳工艺,并通过中试放大,考察工艺的稳定性,并与原工艺进行对比研究。结果最佳工艺为混合药材粉碎成中粉粒度、3罐逆流提取,每罐每次加入12倍量水、提取溶剂保持在70℃提取,每次提取40min。结论罐组式逆流提取技术应用于本品的提取工艺中具有显著性优势,优选的工艺参数稳定可行。Objective Determine the multi -stage countercurrent extraction process of Shuangzeqingzhi granule technology upgrade . Methods Adopt the method of single factor and orthogonal test to the transfer of rhubarb phenol ratio and extract yield as the comprehensive e -valuation index, add water, extraction time, extraction temperature and medicinal particle size effect on extraction technology of comprehen -sive, to determine the best process, and compared with the original process research .Result Optimum process for mixing crushed into me-dicinal materials of powder particle size , 3 cans of countercurrent extraction , every time can join 12 times the amount of water, extracting sol-vent at 70℃ extraction, extraction of 40 minutes at a time.Conculsion The multi -stage countercurrent extraction applied in the extraction process of this product has a significant advantage , optimizing the process parameters of stability is feasible .

关 键 词：双泽清脂颗粒 罐组式逆流提取 正交试验 技术改造 

分 类 号：R284[医药卫生—中药学]